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dc.contributor.authorVölzke, Henry
dc.contributor.authorNauck, Matthias
dc.contributor.authorRettig, Rainer
dc.contributor.authorDörr, Marcus
dc.contributor.authorHigham, Claire E
dc.contributor.authorBrabant, Georg E
dc.contributor.authorWallaschofski, Henri
dc.date.accessioned2010-02-09T11:12:33Z
dc.date.available2010-02-09T11:12:33Z
dc.date.issued2009-11
dc.identifier.citationAssociation between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample. 2009, 161 (5):705-13 Eur. J. Endocrinol.en
dc.identifier.issn1479-683X
dc.identifier.pmid19690083
dc.identifier.doi10.1530/EJE-09-0374
dc.identifier.urihttp://hdl.handle.net/10541/91573
dc.description.abstractCONTEXT: It is assumed that hepatic steatosis plays a role in the development and progression of the metabolic syndrome and its cardiovascular sequelae. Low serum IGF1 levels might mediate these associations. OBJECTIVES: The aims of this study were i) to investigate the associations of hepatic steatosis with serum IGF1 and IGF binding protein-3 (IGFBP-3) levels using ultrasound and serum alanine aminotransaminase (ALT) data to define hepatic steatosis, and ii) to analyze the specific role of alcohol consumption in this context. DESIGN: We analyzed data from the population-based Study of Health in Pomerania. METHODS: We used data from 3863 subjects (1971 women) aged 20-79 years who had no history of viral hepatitis, liver cirrhosis, or malignant diseases. Liver hyperechogenicity was diagnosed using ultrasound. Serum IGF1 and IGFBP-3 levels were determined by automated two-site chemiluminescence immunoassays. RESULTS: Hyperechogenic liver pattern was associated with low serum IGF1 levels and low serum IGF1/IGFBP-3 ratios. The lowest serum IGF1 and IGF1/IGFBP-3 values and highest IGFBP-3 levels were present in subjects who had a hyperechogenic liver pattern and increased serum ALT levels. All of these associations were independent of alcohol consumption. CONCLUSIONS: Our data show that hepatic steatosis is associated with low serum IGF1 levels. This association is independent of alcohol consumption.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAlanine Transaminase
dc.subject.meshAlcohol Drinking
dc.subject.meshAspartate Aminotransferases
dc.subject.meshCross-Sectional Studies
dc.subject.meshFatty Liver
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInsulin-Like Growth Factor Binding Proteins
dc.subject.meshInsulin-Like Growth Factor I
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMultivariate Analysis
dc.subject.meshTransferrin
dc.subject.meshYoung Adult
dc.subject.meshgamma-Glutamyltransferase
dc.titleAssociation between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample.en
dc.typeArticleen
dc.contributor.departmentInstitute of Community Medicine Institute of Clinical Chemistry and Laboratory Medicine Institute of Physiology Department of Internal Medicine B, University of Greifswald, Greifswald D-17487, Germany. voelzke@uni-greifswald.deen
dc.identifier.journalEuropean Journal of Endocrinologyen
refterms.dateFOA2020-09-17T14:43:17Z
html.description.abstractCONTEXT: It is assumed that hepatic steatosis plays a role in the development and progression of the metabolic syndrome and its cardiovascular sequelae. Low serum IGF1 levels might mediate these associations. OBJECTIVES: The aims of this study were i) to investigate the associations of hepatic steatosis with serum IGF1 and IGF binding protein-3 (IGFBP-3) levels using ultrasound and serum alanine aminotransaminase (ALT) data to define hepatic steatosis, and ii) to analyze the specific role of alcohol consumption in this context. DESIGN: We analyzed data from the population-based Study of Health in Pomerania. METHODS: We used data from 3863 subjects (1971 women) aged 20-79 years who had no history of viral hepatitis, liver cirrhosis, or malignant diseases. Liver hyperechogenicity was diagnosed using ultrasound. Serum IGF1 and IGFBP-3 levels were determined by automated two-site chemiluminescence immunoassays. RESULTS: Hyperechogenic liver pattern was associated with low serum IGF1 levels and low serum IGF1/IGFBP-3 ratios. The lowest serum IGF1 and IGF1/IGFBP-3 values and highest IGFBP-3 levels were present in subjects who had a hyperechogenic liver pattern and increased serum ALT levels. All of these associations were independent of alcohol consumption. CONCLUSIONS: Our data show that hepatic steatosis is associated with low serum IGF1 levels. This association is independent of alcohol consumption.


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