Association between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample.
Higham, Claire E
Brabant, Georg E
AffiliationInstitute of Community Medicine Institute of Clinical Chemistry and Laboratory Medicine Institute of Physiology Department of Internal Medicine B, University of Greifswald, Greifswald D-17487, Germany. email@example.com
MetadataShow full item record
AbstractCONTEXT: It is assumed that hepatic steatosis plays a role in the development and progression of the metabolic syndrome and its cardiovascular sequelae. Low serum IGF1 levels might mediate these associations. OBJECTIVES: The aims of this study were i) to investigate the associations of hepatic steatosis with serum IGF1 and IGF binding protein-3 (IGFBP-3) levels using ultrasound and serum alanine aminotransaminase (ALT) data to define hepatic steatosis, and ii) to analyze the specific role of alcohol consumption in this context. DESIGN: We analyzed data from the population-based Study of Health in Pomerania. METHODS: We used data from 3863 subjects (1971 women) aged 20-79 years who had no history of viral hepatitis, liver cirrhosis, or malignant diseases. Liver hyperechogenicity was diagnosed using ultrasound. Serum IGF1 and IGFBP-3 levels were determined by automated two-site chemiluminescence immunoassays. RESULTS: Hyperechogenic liver pattern was associated with low serum IGF1 levels and low serum IGF1/IGFBP-3 ratios. The lowest serum IGF1 and IGF1/IGFBP-3 values and highest IGFBP-3 levels were present in subjects who had a hyperechogenic liver pattern and increased serum ALT levels. All of these associations were independent of alcohol consumption. CONCLUSIONS: Our data show that hepatic steatosis is associated with low serum IGF1 levels. This association is independent of alcohol consumption.
CitationAssociation between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample. 2009, 161 (5):705-13 Eur. J. Endocrinol.
JournalEuropean Journal of Endocrinology
- Association between hepatic steatosis and serum liver enzyme levels with atrial fibrillation in the general population: The Study of Health in Pomerania (SHIP).
- Authors: Markus MR, Meffert PJ, Baumeister SE, Lieb W, Siewert U, Schipf S, Koch M, Kors JA, Felix SB, Dörr M, Targher G, Völzke H
- Issue date: 2016 Feb
- The ratio of insulin-like growth factor-I/insulin-like growth factor-binding protein-3 in sera of patients with hepatitis C virus-related chronic liver disease as a predictive marker of insulin resistance.
- Authors: Himoto T, Tani J, Miyoshi H, Yoneyama H, Mori H, Inukai M, Masugata H, Goda F, Senda S, Haba R, Masaki T
- Issue date: 2013 Jan
- Association between hepatic steatosis, insulin resistance and hyperinsulinaemia as related to hypertension in alcohol consumers and obese people.
- Authors: Ikai E, Ishizaki M, Suzuki Y, Ishida M, Noborizaka Y, Yamada Y
- Issue date: 1995 Feb
- Association of serum IGF1 with endothelial function: results from the population-based study of health in Pomerania.
- Authors: Empen K, Lorbeer R, Völzke H, Robinson DM, Friedrich N, Krebs A, Nauck M, Reffelmann T, Ewert R, Felix SB, Wallaschofski H, Dörr M
- Issue date: 2010 Oct
- Inverse association between serum free thyroxine levels and hepatic steatosis: results from the Study of Health in Pomerania.
- Authors: Ittermann T, Haring R, Wallaschofski H, Baumeister SE, Nauck M, Dörr M, Lerch MM, Meyer zu Schwabedissen HE, Rosskopf D, Völzke H
- Issue date: 2012 Jun