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dc.contributor.authorO'Connor, James P B
dc.contributor.authorNaish, Josephine H
dc.contributor.authorParker, Geoff J M
dc.contributor.authorWaterton, John C
dc.contributor.authorWatson, Yvonne
dc.contributor.authorJayson, Gordon C
dc.contributor.authorBuonaccorsi, Giovanni A
dc.contributor.authorCheung, Susan
dc.contributor.authorBuckley, David L
dc.contributor.authorMcGrath, Deirdre M
dc.contributor.authorWest, Catharine M L
dc.contributor.authorDavidson, Susan E
dc.contributor.authorRoberts, Caleb
dc.contributor.authorMills, Samantha J
dc.contributor.authorMitchell, Claire L
dc.contributor.authorHope, Lynn
dc.contributor.authorTon, N Chan
dc.contributor.authorJackson, Alan
dc.date.accessioned2010-02-09T11:05:31Z
dc.date.available2010-02-09T11:05:31Z
dc.date.issued2009-11-15
dc.identifier.citationPreliminary study of oxygen-enhanced longitudinal relaxation in MRI: a potential novel biomarker of oxygenation changes in solid tumors. 2009, 75 (4):1209-15 Int. J. Radiat. Oncol. Biol. Phys.en
dc.identifier.issn1879-355X
dc.identifier.pmid19327904
dc.identifier.doi10.1016/j.ijrobp.2008.12.040
dc.identifier.urihttp://hdl.handle.net/10541/91533
dc.description.abstractPURPOSE: There is considerable interest in developing non-invasive methods of mapping tumor hypoxia. Changes in tissue oxygen concentration produce proportional changes in the magnetic resonance imaging (MRI) longitudinal relaxation rate (R(1)). This technique has been used previously to evaluate oxygen delivery to healthy tissues and is distinct from blood oxygenation level-dependent (BOLD) imaging. Here we report application of this method to detect alteration in tumor oxygenation status. METHODS AND MATERIALS: Ten patients with advanced cancer of the abdomen and pelvis underwent serial measurement of tumor R(1) while breathing medical air (21% oxygen) followed by 100% oxygen (oxygen-enhanced MRI). Gadolinium-based dynamic contrast-enhanced MRI was then performed to compare the spatial distribution of perfusion with that of oxygen-induced DeltaR(1). RESULTS: DeltaR(1) showed significant increases of 0.021 to 0.058 s(-1) in eight patients with either locally recurrent tumor from cervical and hepatocellular carcinomas or metastases from ovarian and colorectal carcinomas. In general, there was congruency between perfusion and oxygen concentration. However, regional mismatch was observed in some tumor cores. Here, moderate gadolinium uptake (consistent with moderate perfusion) was associated with low area under the DeltaR(1) curve (consistent with minimal increase in oxygen concentration). CONCLUSIONS: These results provide evidence that oxygen-enhanced longitudinal relaxation can monitor changes in tumor oxygen concentration. The technique shows promise in identifying hypoxic regions within tumors and may enable spatial mapping of change in tumor oxygen concentration.
dc.language.isoenen
dc.subjectAbdominal Canceren
dc.subjectLiver Canceren
dc.subjectOvarian Canceren
dc.subjectPelvic Canceren
dc.subjectPeritoneal Canceren
dc.subject.meshAbdominal Neoplasms
dc.subject.meshAdenocarcinoma
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshArea Under Curve
dc.subject.meshCarcinoma, Hepatocellular
dc.subject.meshCarcinoma, Squamous Cell
dc.subject.meshCell Hypoxia
dc.subject.meshContrast Media
dc.subject.meshFemale
dc.subject.meshGadolinium
dc.subject.meshHumans
dc.subject.meshLiver Neoplasms
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOmentum
dc.subject.meshOvarian Neoplasms
dc.subject.meshOxygen
dc.subject.meshPelvic Neoplasms
dc.subject.meshPeritoneal Neoplasms
dc.titlePreliminary study of oxygen-enhanced longitudinal relaxation in MRI: a potential novel biomarker of oxygenation changes in solid tumors.en
dc.typeArticleen
dc.contributor.departmentImaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom. james.o'connor@manchester.ac.uken
dc.identifier.journalInternational Journal of Radiation Oncology, Biology, Physicsen
html.description.abstractPURPOSE: There is considerable interest in developing non-invasive methods of mapping tumor hypoxia. Changes in tissue oxygen concentration produce proportional changes in the magnetic resonance imaging (MRI) longitudinal relaxation rate (R(1)). This technique has been used previously to evaluate oxygen delivery to healthy tissues and is distinct from blood oxygenation level-dependent (BOLD) imaging. Here we report application of this method to detect alteration in tumor oxygenation status. METHODS AND MATERIALS: Ten patients with advanced cancer of the abdomen and pelvis underwent serial measurement of tumor R(1) while breathing medical air (21% oxygen) followed by 100% oxygen (oxygen-enhanced MRI). Gadolinium-based dynamic contrast-enhanced MRI was then performed to compare the spatial distribution of perfusion with that of oxygen-induced DeltaR(1). RESULTS: DeltaR(1) showed significant increases of 0.021 to 0.058 s(-1) in eight patients with either locally recurrent tumor from cervical and hepatocellular carcinomas or metastases from ovarian and colorectal carcinomas. In general, there was congruency between perfusion and oxygen concentration. However, regional mismatch was observed in some tumor cores. Here, moderate gadolinium uptake (consistent with moderate perfusion) was associated with low area under the DeltaR(1) curve (consistent with minimal increase in oxygen concentration). CONCLUSIONS: These results provide evidence that oxygen-enhanced longitudinal relaxation can monitor changes in tumor oxygen concentration. The technique shows promise in identifying hypoxic regions within tumors and may enable spatial mapping of change in tumor oxygen concentration.


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