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    Preliminary study of oxygen-enhanced longitudinal relaxation in MRI: a potential novel biomarker of oxygenation changes in solid tumors.

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    Authors
    O'Connor, James P B
    Naish, Josephine H
    Parker, Geoff J M
    Waterton, John C
    Watson, Yvonne
    Jayson, Gordon C
    Buonaccorsi, Giovanni A
    Cheung, Susan
    Buckley, David L
    McGrath, Deirdre M
    West, Catharine M L
    Davidson, Susan E
    Roberts, Caleb
    Mills, Samantha J
    Mitchell, Claire L
    Hope, Lynn
    Ton, N Chan
    Jackson, Alan
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    Affiliation
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom. james.o'connor@manchester.ac.uk
    Issue Date
    2009-11-15
    
    Metadata
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    Abstract
    PURPOSE: There is considerable interest in developing non-invasive methods of mapping tumor hypoxia. Changes in tissue oxygen concentration produce proportional changes in the magnetic resonance imaging (MRI) longitudinal relaxation rate (R(1)). This technique has been used previously to evaluate oxygen delivery to healthy tissues and is distinct from blood oxygenation level-dependent (BOLD) imaging. Here we report application of this method to detect alteration in tumor oxygenation status. METHODS AND MATERIALS: Ten patients with advanced cancer of the abdomen and pelvis underwent serial measurement of tumor R(1) while breathing medical air (21% oxygen) followed by 100% oxygen (oxygen-enhanced MRI). Gadolinium-based dynamic contrast-enhanced MRI was then performed to compare the spatial distribution of perfusion with that of oxygen-induced DeltaR(1). RESULTS: DeltaR(1) showed significant increases of 0.021 to 0.058 s(-1) in eight patients with either locally recurrent tumor from cervical and hepatocellular carcinomas or metastases from ovarian and colorectal carcinomas. In general, there was congruency between perfusion and oxygen concentration. However, regional mismatch was observed in some tumor cores. Here, moderate gadolinium uptake (consistent with moderate perfusion) was associated with low area under the DeltaR(1) curve (consistent with minimal increase in oxygen concentration). CONCLUSIONS: These results provide evidence that oxygen-enhanced longitudinal relaxation can monitor changes in tumor oxygen concentration. The technique shows promise in identifying hypoxic regions within tumors and may enable spatial mapping of change in tumor oxygen concentration.
    Citation
    Preliminary study of oxygen-enhanced longitudinal relaxation in MRI: a potential novel biomarker of oxygenation changes in solid tumors. 2009, 75 (4):1209-15 Int. J. Radiat. Oncol. Biol. Phys.
    Journal
    International Journal of Radiation Oncology, Biology, Physics
    URI
    http://hdl.handle.net/10541/91533
    DOI
    10.1016/j.ijrobp.2008.12.040
    PubMed ID
    19327904
    Type
    Article
    Language
    en
    ISSN
    1879-355X
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijrobp.2008.12.040
    Scopus Count
    Collections
    All Christie Publications
    Medical Oncology
    Academic Department of Radiation Oncology - ADRO

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