Assessing the effect of a contouring protocol on postprostatectomy radiotherapy clinical target volumes and interphysician variation.
AuthorsMitchell, Darren M
Perry, Lesley A
Wylie, James P
Cowan, Richard A
Livsey, Jacqueline E
Logue, John P
AffiliationDepartment of Clinical Oncology, Christie Hospital, Manchester, United Kingdom. firstname.lastname@example.org
MetadataShow full item record
AbstractPURPOSE: To compare postprostatectomy clinical target volume (CTV) delineation before and after the introduction of a contouring protocol and to investigate its effect on interphysician variability METHODS AND MATERIALS: Six site-specialized radiation oncologists independently delineated a CTV on the computed tomography (CT) scans of 3 patients who had received postprostatectomy radiotherapy. At least 3 weeks later this was repeated, but with the physicians adhering to the contouring protocol from the Medical Research Council's Radiotherapy and Androgen Deprivation In Combination After Local Surgery (RADICALS) trial. The volumes obtained before and after the protocol were compared and the effect of the protocol on interphysician variability assessed. RESULTS: An increase in mean CTV for all patients of 40.7 to 53.9 cm(3) was noted as a result of observing the protocol, with individual increases in the mean CTV of 65%, 15%, and 24% for Patients 1, 2, and 3 respectively. A reduction in interphysician variability was noted when the protocol was used. CONCLUSIONS: Substantial interphysician variation in target volume delineation for postprostatectomy radiotherapy exists, which can be reduced by the use of a contouring protocol. The RADICALS contouring protocol increases the target volumes when compared with those volumes typically applied at our center. The effect of treating larger volumes on the therapeutic ratio and resultant toxicity should be carefully monitored, particularly if the same dose-response as documented in radical prostate radiotherapy applies to the adjuvant and salvage setting. Prostate cancer, Postprostatectomy, Radiotherapy, Target volume.
CitationAssessing the effect of a contouring protocol on postprostatectomy radiotherapy clinical target volumes and interphysician variation. 2009, 75 (4):990-3 Int. J. Radiat. Oncol. Biol. Phys.
JournalInternational Journal of Radiation Oncology, Biology, Physics
- [Changes in target volumes definition by using MRI for prostate bed radiotherapy planning--preliminary results].
- Authors: Sefrová J, Paluska, Odrázka K, Belobradek Z, Hoffmann P, Prosvic P, Brod'ák M, Louda M, Macingová Z, Vosmik M
- Issue date: 2010
- Development of RTOG consensus guidelines for the definition of the clinical target volume for postoperative conformal radiation therapy for prostate cancer.
- Authors: Michalski JM, Lawton C, El Naqa I, Ritter M, O'Meara E, Seider MJ, Lee WR, Rosenthal SA, Pisansky T, Catton C, Valicenti RK, Zietman AL, Bosch WR, Sandler H, Buyyounouski MK, Ménard C
- Issue date: 2010 Feb 1
- Anatomic variations due to radical prostatectomy. Impact on target volume definition and dose-volume parameters of rectum and bladder.
- Authors: Sanguineti G, Castellone P, Foppiano F, Franzone P, Marcenaro M, Tognoni P, Bolognesi A, Ceresoli GL, Fiorino C
- Issue date: 2004 Sep
- Magnetic resonance imaging in postprostatectomy radiotherapy planning.
- Authors: Sefrova J, Odrazka K, Paluska P, Belobradek Z, Brodak M, Dolezel M, Prosvic P, Macingova Z, Vosmik M, Hoffmann P, Louda M, Nejedla A
- Issue date: 2012 Feb 1
- Magnetic resonance imaging for prostate bed radiotherapy planning: An inter- and intra-observer variability study.
- Authors: Barkati M, Simard D, Taussky D, Delouya G
- Issue date: 2016 Apr