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    Adding more content to screening: reactivation of FOXO as a therapeutic strategy.

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    Authors
    Zanella, Fabian
    Carnero, Amancio
    Affiliation
    Experimental Therapeutics Programme, Spanish National Cancer Research Centre, Madrid, Spain.
    Issue Date
    2009-10
    
    Metadata
    Show full item record
    Abstract
    The discovery of novel targets that can be pharmacologically exploited to lead to a better disease outcome has long been an aim of biomedical research. At present, the technology and robotisation available have pushed the search for novel molecules to a high-throughput screening (HTS) context, making it possible to screen several hundreds of compounds or genes in a single day. High-content screenings (HCS) have added a refined complexity to the screening processes, as the information drawn from an image- based assay is more complete than the monoparametric readouts obtained in classical HTS assays. Here, we review the development of HCS platforms to identify molecules influencing FOXO nuclear relocation and activation as pharmacological targets, their applicability and the future directions of the screening field.
    Citation
    Adding more content to screening: reactivation of FOXO as a therapeutic strategy. 2009, 11 (10):651-8 Clin Transl Oncol
    Journal
    Clinical & Translational Oncology
    URI
    http://hdl.handle.net/10541/91485
    DOI
    10.1007/s12094-009-0420-0
    PubMed ID
    19828407
    Type
    Article
    Language
    en
    ISSN
    1699-3055
    ae974a485f413a2113503eed53cd6c53
    10.1007/s12094-009-0420-0
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research
    Medical Oncology

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