Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats.
Affiliation
Institute for Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany.Issue Date
2009-12-07
Metadata
Show full item recordAbstract
Obesity is an increasing socio-economic health problem. Diet-induced obese (DIO) rodents are widely used as a model of obesity in humans. However, there is no comprehensive data about the behavioral phenotype of DIO rodents. Therefore, the aim of the present study was to determine whether a high-fat-diet changes behavioral patterns of DIO Fischer 344 (F344) rats in comparison with lean littermates. The behavioral tests (homecage, holeboard, social interaction, and hotplate) were performed in 28 normal-weight and 28 male DIO F344 rats (mean age: 16 weeks) and revealed a significantly higher level of anxiety- and aggression-related parameters in obese rats, whereas their pain threshold was significantly lower. Fitting to a different behavioral response, basal corticosterone levels (measured by RIA) of obese animals were significantly elevated (16.0ng/ml vs. 12.5ng/ml; p<0.01). We conclude that obese rats differ in various aspects from their lean littermates. The altered behavioral characteristics displayed by DIO F344 rats have to be considered in further experiments involving DIO rodents.Citation
Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats. 2009, 98 (5):563-9 Physiol. Behav.Journal
Physiology & BehaviorDOI
10.1016/j.physbeh.2009.09.003PubMed ID
19751751Type
ArticleLanguage
enISSN
1873-507Xae974a485f413a2113503eed53cd6c53
10.1016/j.physbeh.2009.09.003
Scopus Count
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