Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats.
AffiliationInstitute for Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany.
MetadataShow full item record
AbstractObesity is an increasing socio-economic health problem. Diet-induced obese (DIO) rodents are widely used as a model of obesity in humans. However, there is no comprehensive data about the behavioral phenotype of DIO rodents. Therefore, the aim of the present study was to determine whether a high-fat-diet changes behavioral patterns of DIO Fischer 344 (F344) rats in comparison with lean littermates. The behavioral tests (homecage, holeboard, social interaction, and hotplate) were performed in 28 normal-weight and 28 male DIO F344 rats (mean age: 16 weeks) and revealed a significantly higher level of anxiety- and aggression-related parameters in obese rats, whereas their pain threshold was significantly lower. Fitting to a different behavioral response, basal corticosterone levels (measured by RIA) of obese animals were significantly elevated (16.0ng/ml vs. 12.5ng/ml; p<0.01). We conclude that obese rats differ in various aspects from their lean littermates. The altered behavioral characteristics displayed by DIO F344 rats have to be considered in further experiments involving DIO rodents.
CitationDiet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats. 2009, 98 (5):563-9 Physiol. Behav.
JournalPhysiology & Behavior
- F-DIO obesity-prone rat is insulin resistant before obesity onset.
- Authors: Levin BE, Magnan C, Migrenne S, Chua SC Jr, Dunn-Meynell AA
- Issue date: 2005 Sep
- Assessment of diet-induced obese rats as an obesity model by comparative functional genomics.
- Authors: Li S, Zhang HY, Hu CC, Lawrence F, Gallagher KE, Surapaneni A, Estrem ST, Calley JN, Varga G, Dow ER, Chen Y
- Issue date: 2008 Apr
- Reduced brain CRH and GR mRNA expression precedes obesity in juvenile rats bred for diet-induced obesity.
- Authors: Michel C, Dunn-Meynell A, Levin BE
- Issue date: 2004 Oct 5
- [The study on mechanism of appetite regulation in diet-induced obesity resistant rats].
- Authors: Liu R, Sun CH, Weng Y
- Issue date: 2005 Mar
- A new obesity-prone, glucose-intolerant rat strain (F.DIO).
- Authors: Levin BE, Dunn-Meynell AA, McMinn JE, Alperovich M, Cunningham-Bussel A, Chua SC Jr
- Issue date: 2003 Nov