• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Artis, David
    Humphreys, Neil E
    Bancroft, Allison J
    Rothwell, Nancy J
    Potten, Christopher S
    Grencis, Richard K
    Affiliation
    Immunology Group, School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom. mqbsszda@man.ac.uk
    Issue Date
    1999-10-04
    
    Metadata
    Show full item record
    Abstract
    In vivo manipulation of cytokine and/or cytokine receptor expression has previously shown that resistance to infection with the caecum-dwelling helminth Trichuris muris is dependent on interleukin (IL)-4 and IL-13 while susceptibility is associated with a T helper cell type 1 (Th1) cytokine response. Using gene-targeted mice deficient in tumor necrosis factor (TNF) receptor signaling and anti-TNF-alpha monoclonal antibody treatment, we have extended these studies to reveal a critical role for TNF-alpha in regulation of Th2 cytokine-mediated host protection. In vivo blockade of TNF-alpha in normally resistant mice, although not altering IL-4, IL-5, or IL-13 production in the draining lymph node, significantly delayed worm expulsion for the duration of treatment. IL-13-mediated worm expulsion in IL-4 knockout (KO) mice was also shown to be TNF-alpha dependent, and could be enhanced by administration of recombinant TNF-alpha. Furthermore, TNF receptor KO mice failed to expel T. muris, producing high levels of parasite-specific immunoglobulin G2a and the generation of a predominantly Th1 response, suggesting that the absence of TNF function from the onset of infection dramatically alters the phenotype of the response. These results provide the first demonstration of the role of TNF-alpha in regulating Th2 cytokine-mediated responses at mucosal sites, and have implications for the design of rational therapies against helminth infection and allergy.
    Citation
    Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. 1999, 190 (7):953-62 J. Exp. Med.
    Journal
    Journal of Experimental Medicine
    URI
    http://hdl.handle.net/10541/91355
    PubMed ID
    10510085
    Type
    Article
    Language
    en
    ISSN
    0022-1007
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • The role of TNF-alpha in Trichuris muris infection I: influence of TNF-alpha receptor usage, gender and IL-13.
    • Authors: Hayes KS, Bancroft AJ, Grencis RK
    • Issue date: 2007 Nov
    • The role of TNF-alpha in Trichuris muris infection II: global enhancement of ongoing Th1 or Th2 responses.
    • Authors: Hayes KS, Bancroft AJ, Grencis RK
    • Issue date: 2007 Nov
    • Dendritic cells have a crucial role in the production of cytokines in mesenteric lymph nodes of B10.BR mice infected with Trichuris muris.
    • Authors: Koyama K
    • Issue date: 2008 Feb
    • Cytokine-mediated regulation of chronic intestinal helminth infection.
    • Authors: Else KJ, Finkelman FD, Maliszewski CR, Grencis RK
    • Issue date: 1994 Jan 1
    • IL-10 is critical for host resistance and survival during gastrointestinal helminth infection.
    • Authors: Schopf LR, Hoffmann KF, Cheever AW, Urban JF Jr, Wynn TA
    • Issue date: 2002 Mar 1
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.