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    Estrogen receptor-positive proliferating cells in the normal and precancerous breast.

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    Authors
    Shoker, Balvinder S
    Jarvis, Christine
    Clarke, Robert B
    Anderson, Elizabeth
    Hewlett, Joanne
    Davies, Michael P
    Sibson, D Ross
    Sloane, John P
    Affiliation
    Department of Pathology, University of Liverpool, Liverpool. United Kingdom.
    Issue Date
    1999-12
    
    Metadata
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    Abstract
    Recently it has been shown that epithelial cell expression of the estrogen receptor (ER) and that of the proliferation-associated marker Ki-67 are almost mutually exclusive in the normal premenopausal human breast but that coexpression frequently occurs in estrogen receptor-positive (ER+) breast cancers. This coexpression may indicate disordered expression of ER in the cell cycle or failure to suppress division of ER+ cells and could be important in neoplastic transformation. The purpose of this study was to determine whether in situ proliferations known to be associated with different levels of risk for developing breast cancer contain these coexpressing cells and, if so, the stage at which they occur. We found that ER+ proliferating cells were rare in premenopausal lobules but increased with age in the normal breast. There was no difference in nonlesional tissue between cancerous and noncancerous breasts. The percentage of dual-expressing cells was significantly increased, however, in all of the in situ proliferations and correlated positively with the level of risk of developing breast cancer. We suggest that development of at least some human breast cancers is associated with increasing failure to down-regulate ER as cells enter the cycle or to suppress division of ER+ cells. The mechanism may involve the loss of a tumor suppressor gene.
    Citation
    Estrogen receptor-positive proliferating cells in the normal and precancerous breast. 1999, 155 (6):1811-5 Am. J. Pathol.
    Journal
    American Journal of Pathology
    URI
    http://hdl.handle.net/10541/90805
    PubMed ID
    10595909
    Type
    Article
    Language
    en
    ISSN
    0002-9440
    Collections
    All Paterson Institute for Cancer Research

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