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    Does HLA type predispose some individuals to cancer?

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    Authors
    Little, Ann-Margaret
    Stern, Peter L
    Affiliation
    The Anthony Nolan Bone Marrow Trust, The Royal Free Hospital, Hampstead, London, UK NW3 2QG.
    Issue Date
    1999-08
    
    Metadata
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    Abstract
    Polymorphic human major histocompatibility complex (MHC) genes are pivotal to the functioning immune system, and strong autoimmune disease associations with human leukocyte antigens (HLAs) have been established, although the precise mechanisms of these associations are not fully defined. There is now clear evidence of immunosurveillance in cancer, thus it seems reasonable to hypothesize that HLA types might predispose some individuals to particular malignancies. In addition, HLAs could influence the susceptibility or progression of a malignancy, and this might be most apparent in virally associated cancers. This article discusses the results and problems of searching for such HLAs and cancer associations. To date, it appears that no strong associations between HLAs and cancer risk exist.
    Citation
    Does HLA type predispose some individuals to cancer? 1999, 5 (8):337-42 Mol Med Today
    Journal
    Molecular Medicine Today
    URI
    http://hdl.handle.net/10541/90803
    DOI
    10.1016/S1357-4310(99)01524-5
    PubMed ID
    10431166
    Type
    Article
    Language
    en
    ISSN
    1357-4310
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1357-4310(99)01524-5
    Scopus Count
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    All Paterson Institute for Cancer Research

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