Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome.
dc.contributor.author | Burt, E C | |
dc.contributor.author | McGown, Gail | |
dc.contributor.author | Thorncroft, Mary R | |
dc.contributor.author | James, Louise A | |
dc.contributor.author | Birch, Jillian M | |
dc.contributor.author | Varley, Jennifer | |
dc.date.accessioned | 2010-01-28T12:11:33Z | |
dc.date.available | 2010-01-28T12:11:33Z | |
dc.date.issued | 1999-04 | |
dc.identifier.citation | Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome. 1999, 80 (1-2):9-10 Br. J. Cancer | en |
dc.identifier.issn | 0007-0920 | |
dc.identifier.pmid | 10389970 | |
dc.identifier.doi | 10.1038/sj.bjc.6690313 | |
dc.identifier.uri | http://hdl.handle.net/10541/90801 | |
dc.description.abstract | We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested. | |
dc.language.iso | en | en |
dc.subject | Tumour Suppressor Genes | en |
dc.subject | Tumour Suppressor Proteins | en |
dc.subject.mesh | DNA Mutational Analysis | |
dc.subject.mesh | Genes, Tumor Suppressor | |
dc.subject.mesh | Genes, p16 | |
dc.subject.mesh | Genes, p53 | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Li-Fraumeni Syndrome | |
dc.subject.mesh | Mutation | |
dc.subject.mesh | PTEN Phosphohydrolase | |
dc.subject.mesh | Pedigree | |
dc.subject.mesh | Phosphoric Monoester Hydrolases | |
dc.subject.mesh | Tumor Suppressor Proteins | |
dc.title | Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome. | en |
dc.type | Article | en |
dc.contributor.department | CRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, UK. | en |
dc.identifier.journal | British Journal of Cancer | en |
html.description.abstract | We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested. |