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dc.contributor.authorBurt, E C
dc.contributor.authorMcGown, Gail
dc.contributor.authorThorncroft, Mary R
dc.contributor.authorJames, Louise A
dc.contributor.authorBirch, Jillian M
dc.contributor.authorVarley, Jennifer
dc.date.accessioned2010-01-28T12:11:33Z
dc.date.available2010-01-28T12:11:33Z
dc.date.issued1999-04
dc.identifier.citationExclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome. 1999, 80 (1-2):9-10 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid10389970
dc.identifier.doi10.1038/sj.bjc.6690313
dc.identifier.urihttp://hdl.handle.net/10541/90801
dc.description.abstractWe have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested.
dc.language.isoenen
dc.subjectTumour Suppressor Genesen
dc.subjectTumour Suppressor Proteinsen
dc.subject.meshDNA Mutational Analysis
dc.subject.meshGenes, Tumor Suppressor
dc.subject.meshGenes, p16
dc.subject.meshGenes, p53
dc.subject.meshHumans
dc.subject.meshLi-Fraumeni Syndrome
dc.subject.meshMutation
dc.subject.meshPTEN Phosphohydrolase
dc.subject.meshPedigree
dc.subject.meshPhosphoric Monoester Hydrolases
dc.subject.meshTumor Suppressor Proteins
dc.titleExclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome.en
dc.typeArticleen
dc.contributor.departmentCRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren
html.description.abstractWe have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested.


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