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    Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome.

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    Authors
    Burt, E C
    McGown, Gail
    Thorncroft, Mary R
    James, Louise A
    Birch, Jillian M
    Varley, Jennifer
    Affiliation
    CRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, UK.
    Issue Date
    1999-04
    
    Metadata
    Show full item record
    Abstract
    We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested.
    Citation
    Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome. 1999, 80 (1-2):9-10 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/90801
    DOI
    10.1038/sj.bjc.6690313
    PubMed ID
    10389970
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6690313
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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