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dc.contributor.authorBooth, Catherine
dc.contributor.authorHargreaves, Danielle F
dc.contributor.authorO'Shea, Julie A
dc.contributor.authorPotten, Christopher S
dc.date.accessioned2010-01-28T10:58:38Z
dc.date.available2010-01-28T10:58:38Z
dc.date.issued1999-10-01
dc.identifier.citationIn vivo administration of genistein has no effect on small intestinal epithelial proliferation and apoptosis, but a modest effect on clonogen survival. 1999, 144 (2):169-75 Cancer Lett.en
dc.identifier.issn0304-3835
dc.identifier.pmid10529017
dc.identifier.doi10.1016/S0304-3835(99)00220-7
dc.identifier.urihttp://hdl.handle.net/10541/90789
dc.description.abstractThe soya metabolite genistein possesses anti-proliferative, pro-apoptotic activities in intestinal epithelial cells in vitro and may reduce epithelial cancer incidence. This could involve cell cycle arrest/apoptosis in the proliferative or clonogenic cells. We investigated the effects of genistein on the small intestinal epithelium in vivo. No effect on the number or distribution of proliferative cells in the crypts was detected. Similarly, no change in spontaneous apoptotic cell incidence or the characteristic stem cell apoptotic response following low dose irradiation was observed. Genistein afforded a modest decrease in clonogen radiosensitivity. Hence, using a range of dosing protocols, sub-cutaneous administration of genistein for periods of up to 1 week did not alter intestinal epithelial homeostasis.
dc.language.isoenen
dc.subjectOestrogen Receptor Modulatorsen
dc.subject.meshAnimals
dc.subject.meshAnticarcinogenic Agents
dc.subject.meshApoptosis
dc.subject.meshCell Division
dc.subject.meshCell Survival
dc.subject.meshClone Cells
dc.subject.meshEpithelial Cells
dc.subject.meshEstradiol
dc.subject.meshEstrogen Receptor Modulators
dc.subject.meshGenistein
dc.subject.meshIntestine, Small
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshStem Cells
dc.subject.meshTamoxifen
dc.subject.meshTyrphostins
dc.titleIn vivo administration of genistein has no effect on small intestinal epithelial proliferation and apoptosis, but a modest effect on clonogen survival.en
dc.typeArticleen
dc.contributor.departmentCRC Epithelial Biology Group, Cell and Tissue Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK. cbooth@picr.man.ac.uken
dc.identifier.journalCancer Lettersen
html.description.abstractThe soya metabolite genistein possesses anti-proliferative, pro-apoptotic activities in intestinal epithelial cells in vitro and may reduce epithelial cancer incidence. This could involve cell cycle arrest/apoptosis in the proliferative or clonogenic cells. We investigated the effects of genistein on the small intestinal epithelium in vivo. No effect on the number or distribution of proliferative cells in the crypts was detected. Similarly, no change in spontaneous apoptotic cell incidence or the characteristic stem cell apoptotic response following low dose irradiation was observed. Genistein afforded a modest decrease in clonogen radiosensitivity. Hence, using a range of dosing protocols, sub-cutaneous administration of genistein for periods of up to 1 week did not alter intestinal epithelial homeostasis.


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