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    Human papillomavirus type 16 E2-specific T-helper lymphocyte responses in patients with cervical intraepithelial neoplasia.

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    Authors
    Bontkes, Hetty J
    De Gruijl, Tanja D
    Bijl, Astrid
    Verheijen, René H
    Meijer, Chris J L M
    Scheper, Rik J
    Stern, Peter L
    Burns, Julie E
    Maitland, Norman J
    Walboomers, Jan M
    Affiliation
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
    Issue Date
    1999-09
    
    Metadata
    Show full item record
    Abstract
    T-cell-mediated immune responses against mucosal oncogenic types of human papillomaviruses (HPV) are thought to play a role in the control of the virus infection and its associated cervical lesions. The in vitro production of interleukin-2 by T-helper (Th) cells in response to the C-terminal and N-terminal domains of the HPV-16 E2 protein was determined in 74 women with cytological evidence of premalignant cervical epithelial neoplasia who participated in a non-intervention follow-up (FU) study. Cross-sectional analysis at the end of FU showed that Th cell responses against the C-terminal domain were associated with evidence of previous or present HPV-16 infection as compared to patients with no evidence of any HPV infection (18.9% versus 0%, P = 0.039). Th cell responses against the N-terminal domain were not associated with evidence of HPV-16 infection. No association with disease outcome was observed with Th cell responses against either of the E2 protein domains. However, longitudinal analysis revealed that Th cell responses against the C-terminal domain frequently occur at the time of virus clearance. Whether these responses are responsible for the clearance of the virus is not known.
    Citation
    Human papillomavirus type 16 E2-specific T-helper lymphocyte responses in patients with cervical intraepithelial neoplasia. 1999, 80 ( Pt 9):2453-9 J. Gen. Virol.
    Journal
    Journal of General Virology
    URI
    http://hdl.handle.net/10541/90786
    PubMed ID
    10501501
    Type
    Article
    Language
    en
    ISSN
    0022-1317
    Collections
    All Paterson Institute for Cancer Research

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