• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Roberts, Stephen A
    Spreadborough, Anne R
    Bulman, Barbara
    Barber, James B P
    Evans, D Gareth R
    Scott, David
    Affiliation
    Cancer Research Campaign Biomathematics and Computing Unit, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 4BX, United Kingdom. sroberts@picr.man.ac.uk
    Issue Date
    1999-09
    
    Metadata
    Show full item record
    Abstract
    Many inherited cancer-prone conditions show an elevated sensitivity to the induction of chromosome damage in cells exposed to ionizing radiation, indicative of defects in the processing of DNA damage. We earlier found that 40% of patients with breast cancer and 5%-10% of controls showed evidence of enhanced chromosomal radiosensitivity and that this sensitivity was not age related. We suggested that this could be a marker of cancer-predisposing genes of low penetrance. To further test this hypothesis, we have studied the heritability of radiosensitivity in families of patients with breast cancer. Of 37 first-degree relatives of 16 sensitive patients, 23 (62%) were themselves sensitive, compared with 1 (7%) of 15 first-degree relatives of four patients with normal responses. The distribution of radiosensitivities among the family members showed a trimodal distribution, suggesting the presence of a limited number of major genes determining radiosensitivity. Segregation analysis of 95 family members showed clear evidence of heritability of radiosensitivity, with a single major gene accounting for 82% of the variance between family members. The two alleles combine in an additive (codominant) manner, giving complete heterozygote expression. A better fit was obtained to a model that includes a second, rarer gene with a similar, additive effect on radiosensitivity, but the data are clearly consistent with a range of models. Novel genes involved in predisposition to breast cancer can now be sought through linkage studies using this quantitative trait.
    Citation
    Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer? 1999, 65 (3):784-94 Am. J. Hum. Genet.
    Journal
    American Journal of Human Genetics
    URI
    http://hdl.handle.net/10541/90781
    DOI
    10.1086/302544
    PubMed ID
    10441587
    Type
    Article
    Language
    en
    ISSN
    0002-9297
    ae974a485f413a2113503eed53cd6c53
    10.1086/302544
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Chromosomal radiosensitivity in young cancer patients: possible evidence of genetic predisposition.
    • Authors: Baria K, Warren C, Eden OB, Roberts SA, West CM, Scott D
    • Issue date: 2002 May
    • Chromosomal radiosensitivity as a marker of predisposition to common cancers?
    • Authors: Baria K, Warren C, Roberts SA, West CM, Scott D
    • Issue date: 2001 Apr 6
    • Cancer predisposition, radiosensitivity and the risk of radiation-induced cancers. IV. Prediction of risks in relatives of cancer-predisposed individuals.
    • Authors: Chakraborty R, Little MP, Sankaranarayanan K
    • Issue date: 1998 May
    • Elevated G2 chromosomal radiosensitivity in Irish breast cancer patients: a comparison with other studies.
    • Authors: Howe OL, Daly PA, Seymour C, Ormiston W, Nolan C, Mothersill C
    • Issue date: 2005 May
    • Increased radiosensitivity as an indicator of genes conferring breast cancer susceptibility.
    • Authors: Varga D, Vogel W, Bender A, Surowy H, Maier C, Kreienberg R, Deissler H, Sauer G
    • Issue date: 2007 Dec
    DSpace software (copyright © 2002 - 2019)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.