• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Hemopoietic damage and induction of leukemia in offspring due to preconception paternal irradiation from incorporated plutonium-239.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Lord, Brian I
    Hoyes, Katherine P
    Affiliation
    CRC Section of Haemopoietic Cell and Gene Therapeutics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 4BX, United Kingdom.
    Issue Date
    1999-12
    
    Metadata
    Show full item record
    Abstract
    Preconception paternal irradiation has been implicated in a localized excess of childhood leukemia and non-Hodgkin's lymphoma close to a nuclear reprocessing plant. Other epidemiological studies, however, threw doubt on the validity of this hypothesis. Experimental evidence implicating preconception paternal X rays in the development of lung and skin cancers has also been questioned. In this study, (239)Pu (0, 128 or 256 kBq kg(-1)) was injected into male CBA-H and DBA-2 mice 12 weeks before they were mated with CBA-H and C57BL/6 females. Their offspring were assessed for hematological status at 6 to 18 weeks of age or were treated with either 3.3 Gy whole-body gamma rays or methylnitrosourea (MNU, 50 mg kg(-1)) and monitored for onset of malignancies of the lymphoid and hemopoietic system. As a group, offspring were normal hematologically, but up to 35% of individual mice had femoral cellularities and numbers of spleen and fibroblastoid colony-forming cells outside the normal range. Exposure of the offspring to radiation or MNU significantly increased the rate of incidence of lymphoid and myeloid leukemias. Simulation of the experiments with preconception gamma irradiation indicated that damage to the spermatogenic stem cell was an important factor. It is concluded that preconception paternal irradiation can influence susceptibility of offspring to a subsequent exposure to a carcinogen.
    Citation
    Hemopoietic damage and induction of leukemia in offspring due to preconception paternal irradiation from incorporated plutonium-239. 1999, 152 (6 Suppl):S34-7 Radiat. Res.
    Journal
    Radiation Research
    URI
    http://hdl.handle.net/10541/90778
    PubMed ID
    10564933
    Type
    Article
    Language
    en
    ISSN
    0033-7587
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Induction of lympho-haemopoietic malignancy: impact of preconception paternal irradiation.
    • Authors: Lord BI, Woolford LB, Wang L, McDonald D, Lorimore SA, Stones VA, Wright EG, Scott D
    • Issue date: 1998 Dec
    • Transgenerational effects of preconception paternal contamination with (55)Fe.
    • Authors: Hoyes KP, Lord BI, McCann C, Hendry JH, Morris ID
    • Issue date: 2001 Nov
    • Tumour induction by methyl-nitroso-urea following preconceptional paternal contamination with plutonium-239.
    • Authors: Lord BI, Woolford LB, Wang L, Stones VA, McDonald D, Lorimore SA, Papworth D, Wright EG, Scott D
    • Issue date: 1998 Aug
    • First-generation offspring of male mice exposed to (239)Pu-citrate show no evidence of leukaemia or life shortening.
    • Authors: Selby P, Priest N
    • Issue date: 2005 Apr
    • In utero haemopoietic sensitivity to alpha, beta or X-irradiation in CBA/H mice.
    • Authors: Kozlowski R, Bouffler SD, Haines JW, Harrison JD, Cox R
    • Issue date: 2001 Jul
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.