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    Genotoxicity studies on the azo dye Direct Red 2 using the in vivo mouse bone marrow micronucleus test.

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    Authors
    Rajaguru, P
    Fairbairn, Leslie J
    Ashby, J
    Willington, Mark
    Turner, Suzanne D
    Woolford, L A
    Chinnasamy, Nachimuthu
    Rafferty, Joseph A
    Affiliation
    PSG College of Arts and Science, Coimbatore, India.
    Issue Date
    1999-07-21
    
    Metadata
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    Abstract
    The clastogenicity of the azo dye Direct Red 2 (DR2) has been investigated using the murine bone marrow micronucleus assay. A potent dose-dependent response was observed following oral gavage of DR2 up to 4 mg/kg, after which significant toxicity to the erythroid compartment was observed. The route of administration had a significant effect on the frequency of micronucleus formation: intraperitoneal injection was approximately two-fold less clastogenic than the equivalent dose delivered orally (p<0.05). The requirement for activation of DR2 by intestinal microflora was indicated by the fact that mice given acid-treated water prior to administration of DR2 showed a significant reduction (40%; p<0.001) in micronucleated polychromatic erythrocyte formation. The implications of these findings for the health and safety of occupationally exposed workers are discussed.
    Citation
    Genotoxicity studies on the azo dye Direct Red 2 using the in vivo mouse bone marrow micronucleus test. 1999, 444 (1):175-80 Mutat. Res.
    Journal
    Mutation Research
    URI
    http://hdl.handle.net/10541/90777
    DOI
    10.1016/S1383-5718(99)00081-9
    PubMed ID
    10477352
    Type
    Article
    Language
    en
    ISSN
    0027-5107
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1383-5718(99)00081-9
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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