Genotoxicity studies on the azo dye Direct Red 2 using the in vivo mouse bone marrow micronucleus test.
Fairbairn, Leslie J
Turner, Suzanne D
Woolford, L A
Rafferty, Joseph A
AffiliationPSG College of Arts and Science, Coimbatore, India.
MetadataShow full item record
AbstractThe clastogenicity of the azo dye Direct Red 2 (DR2) has been investigated using the murine bone marrow micronucleus assay. A potent dose-dependent response was observed following oral gavage of DR2 up to 4 mg/kg, after which significant toxicity to the erythroid compartment was observed. The route of administration had a significant effect on the frequency of micronucleus formation: intraperitoneal injection was approximately two-fold less clastogenic than the equivalent dose delivered orally (p<0.05). The requirement for activation of DR2 by intestinal microflora was indicated by the fact that mice given acid-treated water prior to administration of DR2 showed a significant reduction (40%; p<0.001) in micronucleated polychromatic erythrocyte formation. The implications of these findings for the health and safety of occupationally exposed workers are discussed.
CitationGenotoxicity studies on the azo dye Direct Red 2 using the in vivo mouse bone marrow micronucleus test. 1999, 444 (1):175-80 Mutat. Res.
- Genotoxicity studies on the removal of a direct textile dye by a fungal strain, in vivo, using micronucleus and RAPD-PCR techniques on male rats.
- Authors: El-Rahim WM, Khalil WK, Eshak MG
- Issue date: 2008 May
- Lack of genotoxic effect of food dyes amaranth, sunset yellow and tartrazine and their metabolites in the gut micronucleus assay in mice.
- Authors: Poul M, Jarry G, Elhkim MO, Poul JM
- Issue date: 2009 Feb
- A comparison of intraperitoneal and oral gavage administration in comet assay in mouse eight organs.
- Authors: Sekihashi K, Sasaki T, Yamamoto A, Kawamura K, Ikka T, Tsuda S, Sasaki YF
- Issue date: 2001 Jun 27
- CI Acid Red 114.
- Issue date: 1993
- Acid violet 7 and its biodegradation products induce chromosome aberrations, lipid peroxidation, and cholinesterase inhibition in mouse bone marrow.
- Authors: Ben Mansour H, Ayed-Ajmi Y, Mosrati R, Corroler D, Ghedira K, Barillier D, Chekir-Ghedira L
- Issue date: 2010 Aug