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    Photoprotection by topical DNA repair enzymes: molecular correlates of clinical studies.

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    Authors
    Yarosh, Daniel
    O'Connor, Adrienne
    Alas, Lori
    Potten, Christopher S
    Wolf, Peter
    Affiliation
    AGI Dermatics, Freeport, NY 11420, USA. agiderm@aol.com
    Issue Date
    1999-02
    
    Metadata
    Show full item record
    Abstract
    A new approach to photoprotection is to repair DNA damage after UV exposure. This can be accomplished by delivery of a DNA repair enzyme with specificity to UV-induced cyclobutane pyrimidine dimers into skin by means of specially engineered liposomes. Treatment of DNA-repair-deficient xeroderma pigmentosum patients or skin cancer patients with T4N5 liposome lotion containing such DNA repair liposomes increases the removal of DNA damage in the first few hours after treatment. In these studies, a DNA repair effect was observed in some patients treated with heat-inactivated enzyme. Unexpectedly, it was discovered that the heat-inactivated T4 endonuclease V enzyme refolds and recovers enzymatic activity. These studies demonstrate that measurements of molecular changes induced by biological drugs are useful adjuvants to clinical studies.
    Citation
    Photoprotection by topical DNA repair enzymes: molecular correlates of clinical studies. 1999, 69 (2):136-40 Photochem. Photobiol.
    Journal
    Photochemistry and Photobiology
    URI
    http://hdl.handle.net/10541/90776
    DOI
    10.1111/j.1751-1097.1999.tb03265.x
    PubMed ID
    10048308
    Type
    Article
    Language
    en
    ISSN
    0031-8655
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1751-1097.1999.tb03265.x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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