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    Free radical scavenging properties of melanin interaction of eu- and pheo-melanin models with reducing and oxidising radicals.

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    Authors
    Rózanowska, Malgorzata
    Sarna, Tadeusz
    Land, Edward J
    Truscott, T G
    Affiliation
    Department of Biophysics, Institute of Molecular Biology, Jagiellonian University, Kraków, Poland.
    Issue Date
    1999-03
    
    Metadata
    Show full item record
    Abstract
    The human skin and eye melanin is commonly viewed as an efficient photoprotective agent. To elucidate the molecular mechanism of the melanin-dependent photoprotection, we studied the interaction of two synthetic melanins, dopa-melanin and cysteinyldopa-melanin, with a wide range of oxidising and reducing free radicals using the pulse radiolysis technique. We have found that although both types of free radicals could efficiently interact with the synthetic melanins, their radical scavenging properties depended, in a complex way, on the redox potential, the electric charge and the lifetime of the radicals. Repetitive pulsing experiments, in which the free radicals, probing the polymer redox sites, were generated from four different viologens, indicated that the eumelanin model had more reduced than oxidised groups accessible to reaction with the radicals. Although with many radicals studied, melanin interacted via simple one-electron transfer processes, the reaction of both melanins with the strongly oxidising peroxyl radical from carbon tetrachloride, involved radical addition. Our study suggests that the free radical scavenging properties of melanin may be important in the protection of melanotic cells against free radical damage, particularly if the reactive radicals are generated in close proximity to the pigment granules.
    Citation
    Free radical scavenging properties of melanin interaction of eu- and pheo-melanin models with reducing and oxidising radicals. 1999, 26 (5-6):518-25 Free Radic. Biol. Med.
    Journal
    Free Radical Biology & Medicine
    URI
    http://hdl.handle.net/10541/90774
    DOI
    10.1016/S0891-5849(98)00234-2
    PubMed ID
    10218640
    Type
    Article
    Language
    en
    ISSN
    0891-5849
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0891-5849(98)00234-2
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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