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    Mapping dynamic epithelial cell proliferative activity within the oral cavity of man: a new insight into carcinogenesis?

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    Authors
    Thomson, P J
    Potten, Christopher S
    Appleton, D R
    Affiliation
    Department of Oral & Maxillofacial Surgery, The Dental School, University of Newcastle upon Tyne, UK.
    Issue Date
    1999-10
    
    Metadata
    Show full item record
    Abstract
    Our aim was to characterize epithelial cell proliferative activity within the oral cavity and to find out if there were differences between sites with high and low incidence of cancer. A total of 105 samples of clinically normal mucosa were harvested from various intra-oral sites. Excised specimens were incubated in vitro with tritiated thymidine and bromodeoxyuridine to 'double label' cells undergoing DNA synthesis, and enable calculation of the duration of S phase and estimation of variables of cell flux to and from S. Mean labelling indices (percentage of cells within the S phase of the cell cycle) were highest in the floor of mouth (12.3%) and ventral tongue (10.1%), while activity was lowest in the dorsum of tongue (4.3%) and the palate (7.2%), P<0.001. In general, both cell influx and the duration of S increased proportionally to the labelling index. Sites with a high incidence of cancer were characterized by high labelling indices, increased cell influx and a prolonged S phase.
    Citation
    Mapping dynamic epithelial cell proliferative activity within the oral cavity of man: a new insight into carcinogenesis? 1999, 37 (5):377-83 Br J Oral Maxillofac Surg
    Journal
    The British Journal of Oral & Maxillofacial Surgery
    URI
    http://hdl.handle.net/10541/90765
    DOI
    10.1054/bjom.1999.0130
    PubMed ID
    10577752
    Type
    Article
    Language
    en
    ISSN
    0266-4356
    ae974a485f413a2113503eed53cd6c53
    10.1054/bjom.1999.0130
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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