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    Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome.

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    Authors
    De Gruijl, Tanja D
    Bontkes, Hetty J
    Walboomers, Jan M
    Coursaget, Pierre
    Stukart, Marij J
    Dupuy, Catherine
    Kueter, Esther
    Verheijen, René H
    Helmerhorst, Theo J
    Duggan-Keen, Margaret F
    Stern, Peter L
    Meijer, Chris J L M
    Scheper, Rik J
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    Affiliation
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
    Issue Date
    1999-02
    
    Metadata
    Show full item record
    Abstract
    T-helper (Th) cell-dependent IL-2 production and plasma IgG responses to virus-like particles consisting of the human papillomavirus type 16 (HPV-16) major capsid protein L1 (L1-VLP) were determined in patients with cytological evidence of cervical intraepithelial neoplasia (CIN) participating in a non-intervention prospective cohort study. IgG responses were associated with HPV-16 persistence and high-grade CIN lesions, while high frequencies of Th responses were observed in patients with both virus clearance and virus persistence, irrespective of CIN grade. The IgG response was found in conjunction with an IL-2 response to L1-VLP in 87% of the patients. Recognition of the HPV-16 L1 Th epitope (amino acids 311-335) was found to be more closely associated than recognition of L1-VLP as a whole to HPV exposure and CIN development. Among the HPV-16+ patients included in this study, those showing a Th response to amino acids 311-335 were more likely to carry the HLA DRB1*11/DQB1*0301 haplotype, while those showing an IgG response to L1-VLP were more likely to carry DRB1*0101/DQB1*0501. However, neither cell-mediated nor humoral immune responses against HPV-16 L1 appear to be sufficient for the natural control of HPV infection and CIN development.
    Citation
    Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome. 1999, 80 ( Pt 2):399-408 J. Gen. Virol.
    Journal
    Journal of General Virology
    URI
    http://hdl.handle.net/10541/90761
    PubMed ID
    10073700
    Type
    Article
    Language
    en
    ISSN
    0022-1317
    Collections
    All Paterson Institute for Cancer Research

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