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    Late radiation change in the CNS: MR imaging following gadolinium enhancement.

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    Authors
    Norris, A M
    Carrington, Bernadette M
    Slevin, Nicholas J
    Affiliation
    Department of Diagnostic Radiology, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    1997-05
    
    Metadata
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    Abstract
    Magnetic resonance imaging is the best imaging technique for the detection of radiotherapy-induced changes in the central nervous system but there are few studies detailing the MRI appearances of radiation effects following enhancement with intravenous gadolinium. In this paper, gadolinium enhanced MR imaging findings were reviewed in seven patients with evidence of late radiation injury following radiotherapy for primary head and neck tumours. On T1-weighted enhanced sequences, abnormal focal areas were present in the anterior temporal lobes and antero-inferior aspects of the frontal lobes. These lesions were well defined and enhanced intensely following intravenous gadolinium. They were present in the white matter in five patients and involved both grey and white matter in two patients. Cystic components were present in larger lesions in three patients and mass effect was present around the enhancing lesions in four patients. All abnormalities occurred within the radiation treatment portals and corresponded to the distribution of increased signal intensity changes in the brain on T2-weighted images. Late radiation-induced injury should be considered in the differential diagnosis of any intensely enhancing lesion occurring within irradiated brain tissue.
    Citation
    Late radiation change in the CNS: MR imaging following gadolinium enhancement. 1997, 52 (5):356-62 Clin Radiol
    Journal
    Clinical Radiology
    URI
    http://hdl.handle.net/10541/90535
    PubMed ID
    9171789
    Type
    Article
    Language
    en
    ISSN
    0009-9260
    Collections
    All Christie Publications

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