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dc.contributor.authorLogue, John P
dc.contributor.authorSlevin, Nicholas J
dc.date.accessioned2010-01-25T10:09:48Z
dc.date.available2010-01-25T10:09:48Z
dc.date.issued1991-03
dc.identifier.citationCarcinoma of the nasal cavity and paranasal sinuses: an analysis of radical radiotherapy. 1991, 3 (2):84-9 Clin Oncolen
dc.identifier.issn0936-6555
dc.identifier.pmid2031888
dc.identifier.doi10.1016/S0936-6555(05)81169-0
dc.identifier.urihttp://hdl.handle.net/10541/90519
dc.description.abstractA retrospective analysis was conducted of 152 patients with carcinoma of the nasal cavity and paranasal sinuses who were treated with radical radiotherapy between 1975-1984. Stages at presentation were T1 11%, T2 18%, T3 27%, and T4 44%. The median follow-up was 61 months. The overall corrected 5-year survival was 47% and by T stage, T1 86%, T2 82%, T3 49%, T4 25%. Local control was achieved in 45% of cases following radiotherapy. Salvage surgery was attempted in 20 patients where radiotherapy failed and was successful in eight. Nodal disease was present in 6.5% of patients at presentation and 10.5% developed nodal disease after treatment. Nodal disease as sole relapse occurred in four patients and was associated with prolonged survival following radical salvage treatment. Distant metastatic disease occurred in 25 patients and of these 17 (68%) also had locoregional failure. Osteoradionecrosis occurred in three cases, and a further three cases developed bilateral blindness. We conclude that radical radiotherapy achieves results comparable to published data for combined surgery and radiotherapy with acceptable toxicity.
dc.language.isoenen
dc.subjectNose Canceren
dc.subjectParanasal Sinus Canceren
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshCombined Modality Therapy
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNasal Cavity
dc.subject.meshNose Neoplasms
dc.subject.meshParanasal Sinus Neoplasms
dc.subject.meshRetrospective Studies
dc.subject.meshSurvival Rate
dc.titleCarcinoma of the nasal cavity and paranasal sinuses: an analysis of radical radiotherapy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiotherapy and Oncology, Christie Hospital and Holt Radium Institute, Manchester, UK.en
dc.identifier.journalClinical Oncologyen
html.description.abstractA retrospective analysis was conducted of 152 patients with carcinoma of the nasal cavity and paranasal sinuses who were treated with radical radiotherapy between 1975-1984. Stages at presentation were T1 11%, T2 18%, T3 27%, and T4 44%. The median follow-up was 61 months. The overall corrected 5-year survival was 47% and by T stage, T1 86%, T2 82%, T3 49%, T4 25%. Local control was achieved in 45% of cases following radiotherapy. Salvage surgery was attempted in 20 patients where radiotherapy failed and was successful in eight. Nodal disease was present in 6.5% of patients at presentation and 10.5% developed nodal disease after treatment. Nodal disease as sole relapse occurred in four patients and was associated with prolonged survival following radical salvage treatment. Distant metastatic disease occurred in 25 patients and of these 17 (68%) also had locoregional failure. Osteoradionecrosis occurred in three cases, and a further three cases developed bilateral blindness. We conclude that radical radiotherapy achieves results comparable to published data for combined surgery and radiotherapy with acceptable toxicity.


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