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    Neuroendocrine carcinomas of the larynx.

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    Authors
    Logue, John P
    Banerjee, Saumitra S
    Slevin, Nicholas J
    Vasanthan, S
    Affiliation
    Department of Radiotherapy and Oncology, Christie Hospital, Manchester.
    Issue Date
    1991-12
    
    Metadata
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    Abstract
    The clinical and histopathological characteristics of seven cases of Moderately Differentiated Neuroendocrine Carcinomas (MDNEC) and two cases of Poorly Differentiated Neuroendocrine Carcinomas (PDNEC) have been reviewed. The tumours arose in the supraglottis of predominantly elderly men. Two cases had raised levels of urinary 5-hydroxy-indole-acetic acid at presentation but no case developed the carcinoid syndrome. PDNEC were histologically identical to the oat cell type carcinoma of the bronchus and were associated with an extremely aggressive clinical course with both patients dying of widespread metastases within one month of registration. MDNEC also metastasized frequently with four of seven cases dying with widespread disease. The tumours have previously been reported as not being radiosensitive; however three cases remain free of disease following biopsy and radiotherapy alone. The place of radiotherapy in the management of these tumours is discussed.
    Citation
    Neuroendocrine carcinomas of the larynx. 1991, 105 (12):1031-5 J Laryngol Otol
    Journal
    The Journal of Laryngology and Otology
    URI
    http://hdl.handle.net/10541/90517
    PubMed ID
    1664846
    Type
    Article
    Language
    en
    ISSN
    0022-2151
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    All Christie Publications

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