Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: a review.
Homer, Jarrod J
Slevin, Nicholas J
Price, Patricia M
West, Catharine M L
AffiliationAcademic Department of Radiation Oncology, The University of Manchester, Manchester, UK. firstname.lastname@example.org
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AbstractOBJECTIVE: The main aim of this article was to review the clinical and biological factors that have been shown to influence the response of the head and neck squamous cell carcinoma (HNSCC) to primary radiotherapy and briefly discuss how some of these factors could be exploited to improve outcome. DESIGN: Medline based search covering 1982-2006 to identify the HNSCC literature where the effect of clinical and biological factors on locoregional control and overall survival were investigated. RESULTS: Clinical factors are routinely used in management decisions. Nevertheless, identically staged tumours receiving the same treatment may have different outcomes. Biological factors such as hypoxia, proliferation and radio-sensitivity play an important role in radiation response. However, these are not currently used in practise because tests that are clinically reliable and feasible are not available. CONCLUSION: High-quality translational research will allow us to develop biological tests that can be used in routine clinical practise to tailor individual treatment, with the ability to improve patient outcome further by modifying the underlying tumour biology.
CitationClinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: a review. 2007, 32 (5):337-45 Clin Otolaryngol
- Tumor microenvironment in head and neck squamous cell carcinomas: predictive value and clinical relevance of hypoxic markers. A review.
- Authors: Hoogsteen IJ, Marres HA, Bussink J, van der Kogel AJ, Kaanders JH
- Issue date: 2007 Jun
- [The effect of the microenvironment of head and neck cancers on tumor progression].
- Authors: Lukits J
- Issue date: 2009 Mar
- Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck.
- Authors: Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J
- Issue date: 2009 Apr 20
- Tumour cell proliferation under hypoxic conditions in human head and neck squamous cell carcinomas.
- Authors: Wijffels KI, Marres HA, Peters JP, Rijken PF, van der Kogel AJ, Kaanders JH
- Issue date: 2008 Apr
- Oxygen distributions partly explain the radiation response of human squamous cell carcinomas.
- Authors: Okunieff P, de Bie J, Dunphy EP, Terris DJ, Höckel M
- Issue date: 1996 Jul