• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Potential of radiation-induced chromosome aberrations to predict radiosensitivity in human tumour cells.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Coco Martin, J M
    Mooren, E
    Ottenheim, C
    Burrill, Wayne
    Nunez, M I
    Sprong, D
    Bartelink, Harry
    Begg, Adrian C
    Affiliation
    Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam. jose.coco_martin@gist-brocades.infonet.com
    Issue Date
    1999-09
    
    Metadata
    Show full item record
    Abstract
    PURPOSE: To validate whether the number of aberrations could be used as a measure of the radiosensitivity of human tumour cells. If so, this would potentially provide a more rapid method than the colony assay to predict radiocurability in human tumour biopsy material. MATERIALS AND METHODS: A panel of 13 human tumour cell lines was investigated, covering a wide range of radiosensitivities. Fluorescence in situ hybridization (FISH) employing whole chromosome probes was used to detect aberrations. RESULTS: A dose-dependent increase in radiation-induced chromosome aberrations was observed in all cell lines. A good correlation (r=0.90) was found between cell survival and total chromosome aberrations in 12 of the 13 cell lines (92%), with one exception. A poorer correlation was observed between cell survival and stable- (r=0.85) and unstable-type aberrations (r=0.81). Survival-aberration correlations for individual radiation doses were worse, although statistically significant. The exceptional cell line showed significantly more aberrations for a given level of cell kill than expected based on data for the other lines. CONCLUSION: This study indicates that radiation-induced chromosome aberrations can be used as a potential predictor of intrinsic radiosensitivity for the majority of human tumours when more than one dose level is tested. This could aid the design of radiotherapy schedules for each individual patient, or in the decision of whether to use an alternative therapy.
    Citation
    Potential of radiation-induced chromosome aberrations to predict radiosensitivity in human tumour cells. 1999, 75 (9):1161-8 Int. J. Radiat. Biol.
    Journal
    International Journal of Radiation Biology
    URI
    http://hdl.handle.net/10541/90176
    PubMed ID
    10528924
    Type
    Article
    Language
    en
    ISSN
    0955-3002
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Use of fluorescence in situ hybridization to measure chromosome aberrations as a predictor of radiosensitivity in human tumour cells.
    • Authors: Coco-Martin JM, Smeets MF, Poggensee M, Mooren E, Hofland I, van den Brug M, Ottenheim C, Bartelink H, Begg AC
    • Issue date: 1994 Sep
    • Relationship between chromosome aberrations, micronuclei and cell kill in two human tumour cell lines of widely differing radiosensitivity.
    • Authors: Jones LA, Clegg S, Bush C, McMillan TJ, Peacock JH
    • Issue date: 1994 Nov
    • Prediction of human cell radiosensitivity: comparison of clonogenic assay with chromosome aberrations scored using premature chromosome condensation with fluorescence in situ hybridization.
    • Authors: Sasai K, Evans JW, Kovacs MS, Brown JM
    • Issue date: 1994 Dec 1
    • Lethality of radiation-induced chromosome aberrations in human tumour cell lines with different radiosensitivities.
    • Authors: Coco-Martin JM, Ottenheim CP, Bartelink H, Begg AC
    • Issue date: 1996 Mar
    • Use of fluorescence in situ hybridization to determine the relationship between chromosome aberrations and cell survival in eight human fibroblast strains.
    • Authors: Russell NS, Arlett CF, Bartelink H, Begg AC
    • Issue date: 1995 Aug
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.