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dc.contributor.authorMeseda, Clement A
dc.contributor.authorArrand, John R
dc.contributor.authorMackett, Mike
dc.date.accessioned2010-01-20T15:11:03Z
dc.date.available2010-01-20T15:11:03Z
dc.date.issued2000-07
dc.identifier.citationHerpesvirus papio encodes a functional homologue of the Epstein-Barr virus apoptosis suppressor, BHRF1. 2000, 81 (Pt 7):1801-5 J. Gen. Virol.en
dc.identifier.issn0022-1317
dc.identifier.pmid10859386
dc.identifier.urihttp://hdl.handle.net/10541/90141
dc.description.abstractThe human tumour virus Epstein-Barr virus (EBV) encodes a 17 kDa protein, BHRF1, which is a member of the BCL:-2 family and has been shown to suppress apoptosis. The role of this gene in the life-cycle of EBV has not been fully elucidated. In order to identify motifs conserved in herpesviruses and possibly shed light on its function we isolated a BHRF1 homologue from herpesvirus papio (cercopithecine herpesvirus-12) a closely related gammaherpesvirus of baboons. The gene, hvpBHRF1, also encodes a 17 kDa protein which shares 64% identity and 79% similarity with EBV BHRF1 at the amino acid level. In biological assays, hvpBHRF1 and BHRF1 conferred similar levels of protection on human keratinocytes induced to apoptose with cis-platin.
dc.language.isoenen
dc.subject.meshAmino Acid Sequence
dc.subject.meshAnimals
dc.subject.meshApoptosis
dc.subject.meshHumans
dc.subject.meshMolecular Sequence Data
dc.subject.meshOpen Reading Frames
dc.subject.meshPapio
dc.subject.meshProto-Oncogene Proteins c-bcl-2
dc.subject.meshSequence Homology, Amino Acid
dc.subject.meshSimplexvirus
dc.subject.meshViral Proteins
dc.titleHerpesvirus papio encodes a functional homologue of the Epstein-Barr virus apoptosis suppressor, BHRF1.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 9BX, UK.en
dc.identifier.journalThe Journal of General Virologyen
html.description.abstractThe human tumour virus Epstein-Barr virus (EBV) encodes a 17 kDa protein, BHRF1, which is a member of the BCL:-2 family and has been shown to suppress apoptosis. The role of this gene in the life-cycle of EBV has not been fully elucidated. In order to identify motifs conserved in herpesviruses and possibly shed light on its function we isolated a BHRF1 homologue from herpesvirus papio (cercopithecine herpesvirus-12) a closely related gammaherpesvirus of baboons. The gene, hvpBHRF1, also encodes a 17 kDa protein which shares 64% identity and 79% similarity with EBV BHRF1 at the amino acid level. In biological assays, hvpBHRF1 and BHRF1 conferred similar levels of protection on human keratinocytes induced to apoptose with cis-platin.


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