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dc.contributor.authorMorton, Colin A
dc.contributor.authorWhitehurst, Colin
dc.contributor.authorMoore, James V
dc.contributor.authorMacKie, Rona M
dc.date.accessioned2010-01-19T16:49:59Z
dc.date.available2010-01-19T16:49:59Z
dc.date.issued2000-10
dc.identifier.citationComparison of red and green light in the treatment of Bowen's disease by photodynamic therapy. 2000, 143 (4):767-72 Br. J. Dermatol.en
dc.identifier.issn0007-0963
dc.identifier.pmid11069454
dc.identifier.doi10.1046/j.1365-2133.2000.03773.x
dc.identifier.urihttp://hdl.handle.net/10541/90039
dc.description.abstractBACKGROUND: A variety of protocols exist for the treatment of Bowen's disease by photodynamic therapy (PDT) using topical 5-aminolaevulinic acid (5-ALA). OBJECTIVE: To determine the optimal wavelength (red or green light) for this treatment. METHODS: A randomized comparison study of ALA-PDT using red (630 +/- 15 nm) or green (540 +/- 15 nm) light in the treatment of Bowen's disease. RESULTS: The initial clearance rate for lesions treated by red light was 94% (30 of 32) in comparison with 72% (21 of 29) for those lesions receiving green light (P = 0.002). Over the following 12 months, there were two recurrences in the red light group and seven in the green light group reducing the clearance rates to 88% and 48%, respectively. The frequency and severity of pain experienced were similar between the two treatment groups. No hyperthermia, nor significant difference in lesional temperatures, was observed between the wavelengths studied. CONCLUSION: Green light is less effective than red light, at a theoretically equivalent dose, in the treatment of Bowen's disease by topical ALA-PDT.
dc.language.isoenen
dc.subjectCancer Recurrenceen
dc.subjectSkin Canceren
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAminolevulinic Acid
dc.subject.meshBowen's Disease
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Recurrence, Local
dc.subject.meshPhotochemotherapy
dc.subject.meshPhotosensitizing Agents
dc.subject.meshSkin Neoplasms
dc.titleComparison of red and green light in the treatment of Bowen's disease by photodynamic therapy.en
dc.typeArticleen
dc.contributor.departmentUniversity Department of Dermatology, Western Infirmary, Glasgow G11 6NT, UK. camorton@fdri2.fdri.scot.nhs.uken
dc.identifier.journalThe British Journal of Dermatologyen
html.description.abstractBACKGROUND: A variety of protocols exist for the treatment of Bowen's disease by photodynamic therapy (PDT) using topical 5-aminolaevulinic acid (5-ALA). OBJECTIVE: To determine the optimal wavelength (red or green light) for this treatment. METHODS: A randomized comparison study of ALA-PDT using red (630 +/- 15 nm) or green (540 +/- 15 nm) light in the treatment of Bowen's disease. RESULTS: The initial clearance rate for lesions treated by red light was 94% (30 of 32) in comparison with 72% (21 of 29) for those lesions receiving green light (P = 0.002). Over the following 12 months, there were two recurrences in the red light group and seven in the green light group reducing the clearance rates to 88% and 48%, respectively. The frequency and severity of pain experienced were similar between the two treatment groups. No hyperthermia, nor significant difference in lesional temperatures, was observed between the wavelengths studied. CONCLUSION: Green light is less effective than red light, at a theoretically equivalent dose, in the treatment of Bowen's disease by topical ALA-PDT.


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