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dc.contributor.authorLawrence, Nicholas J
dc.contributor.authorMcGown, Alan T
dc.contributor.authorDucki, Sylvie W
dc.contributor.authorHadfield, John A
dc.date.accessioned2010-01-19T16:38:13Z
dc.date.available2010-01-19T16:38:13Z
dc.date.issued2000-04
dc.identifier.citationThe interaction of chalcones with tubulin. 2000, 15 (2):135-41 Anticancer Drug Des.en
dc.identifier.issn0266-9536
dc.identifier.pmid10901301
dc.identifier.urihttp://hdl.handle.net/10541/90036
dc.description.abstractThe chalcone 3,4,3',4',5'-pentamethoxychalcone is a potent cytotoxic agent. A series of chalcones and (E)-4-(4'-hydroxyphenyl)but-3-en-2-one were prepared and assessed for their ability to inhibit cell growth in vitro. The cytotoxicity correlates with their ability to bind to tubulin as measured by immunofluorescence, cell cycle analysis and disruption of microtubule assembly. Some of the chalcones were shown to bind to the type II oestrogen receptor.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents
dc.subject.meshCell Cycle
dc.subject.meshCell Division
dc.subject.meshCell Survival
dc.subject.meshCercopithecus aethiops
dc.subject.meshChalcone
dc.subject.meshDrug Design
dc.subject.meshHumans
dc.subject.meshIndicators and Reagents
dc.subject.meshK562 Cells
dc.subject.meshMicrotubules
dc.subject.meshMolecular Structure
dc.subject.meshPropiophenones
dc.subject.meshStructure-Activity Relationship
dc.subject.meshSwine
dc.subject.meshTubulin
dc.subject.meshVero Cells
dc.titleThe interaction of chalcones with tubulin.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemistry, University of Manchester Institute of Science and Technology, UK. n.lawrence@umist.ac.uken
dc.identifier.journalAnti-Cancer Drug Designen
html.description.abstractThe chalcone 3,4,3',4',5'-pentamethoxychalcone is a potent cytotoxic agent. A series of chalcones and (E)-4-(4'-hydroxyphenyl)but-3-en-2-one were prepared and assessed for their ability to inhibit cell growth in vitro. The cytotoxicity correlates with their ability to bind to tubulin as measured by immunofluorescence, cell cycle analysis and disruption of microtubule assembly. Some of the chalcones were shown to bind to the type II oestrogen receptor.


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