AffiliationMolecular Oncology Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, UK.
MetadataShow full item record
AbstractD-type cyclin homologs have been found in the genomes of herpesviruses associated with neoplasias. They appear to exploit features of G(1) cyclins but extend their properties to allow for deregulation of the cell cycle. Advances in the study of the molecular basis for these novel features as well as the potential role of viral cyclins in tumorigenesis are addressed.
CitationViral-encoded cyclins. 2000, 10 (1):70-4 Curr. Opin. Genet. Dev.
JournalCurrent Opinion in Genetics & Development
- Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins.
- Authors: Swanton C, Mann DJ, Fleckenstein B, Neipel F, Peters G, Jones N
- Issue date: 1997 Nov 13
- Viral cyclins.
- Authors: Mittnacht S, Boshoff C
- Issue date: 2000 May-Jun
- Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication.
- Authors: Laman H, Coverley D, Krude T, Laskey R, Jones N
- Issue date: 2001 Jan
- Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.
- Authors: Laman H, Funes JM, Ye H, Henderson S, Galinanes-Garcia L, Hara E, Knowles P, McDonald N, Boshoff C
- Issue date: 2005 Sep 7
- p21 is a component of active cell cycle kinases.
- Authors: Zhang H, Hannon GJ, Casso D, Beach D
- Issue date: 1994