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dc.contributor.authorKelly, Deirdre A
dc.contributor.authorYoung, Antony R
dc.contributor.authorMcGregor, Jane M
dc.contributor.authorSeed, Paul T
dc.contributor.authorPotten, Christopher S
dc.contributor.authorWalker, Susan L
dc.date.accessioned2009-12-29T11:00:57Z
dc.date.available2009-12-29T11:00:57Z
dc.date.issued2000-02-07
dc.identifier.citationSensitivity to sunburn is associated with susceptibility to ultraviolet radiation-induced suppression of cutaneous cell-mediated immunity. 2000, 191 (3):561-6 J. Exp. Med.en
dc.identifier.issn0022-1007
dc.identifier.pmid10662801
dc.identifier.urihttp://hdl.handle.net/10541/88623
dc.description.abstractSkin cancer incidence is highest in white-skinned people. Within this group, skin types I/II (sun sensitive/tan poorly) are at greater risk than skin types III/IV (sun tolerant/tan well). Studies in mice demonstrate that ultraviolet radiation (UVR)-induced suppression of cell-mediated immune function plays an important role in the development of skin cancer and induces a susceptibility to infectious disease. A similar role is suspected in humans, but we lack quantitative human data to make risk assessments of ambient solar exposure on human health. This study demonstrates that ambient levels of solar UVR, typically experienced within 1 h of exposure to noonday summer sunlight, can suppress contact hypersensitivity (CHS) responses in healthy white-skinned humans in vivo (n = 93). There was a linear relationship between increase in erythema and suppression of CHS (P < 0.001), and a moderate sunburn (two minimal erythema doses [2 MED]) was sufficient to suppress CHS in all volunteers by 93%. However, a single suberythemal exposure of either 0.25 or 0.5 MED suppressed CHS responses by 50 and 80%, respectively, in skin types I/II, whereas 1 MED only suppressed CHS by 40% in skin types III/IV. The two- to threefold greater sensitivity of skin types I/II for a given level of sunburn may play a role in their greater sensitivity to skin cancer.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshButtocks
dc.subject.meshDinitrochlorobenzene
dc.subject.meshDisease Susceptibility
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshDown-Regulation
dc.subject.meshErythema
dc.subject.meshEuropean Continental Ancestry Group
dc.subject.meshGreat Britain
dc.subject.meshHumans
dc.subject.meshImmunity, Cellular
dc.subject.meshIrritants
dc.subject.meshSeasons
dc.subject.meshSkin
dc.subject.meshSunburn
dc.subject.meshUltraviolet Rays
dc.titleSensitivity to sunburn is associated with susceptibility to ultraviolet radiation-induced suppression of cutaneous cell-mediated immunity.en
dc.typeArticleen
dc.contributor.departmentDepartment of Photobiology, St. John's Institute of Dermatology, Guy's , King's and St. Thomas' School of Medicine, King's College London, University of London, St. Thomas Hospital, London, UK.en
dc.identifier.journalThe Journal of Experimental Medicineen
html.description.abstractSkin cancer incidence is highest in white-skinned people. Within this group, skin types I/II (sun sensitive/tan poorly) are at greater risk than skin types III/IV (sun tolerant/tan well). Studies in mice demonstrate that ultraviolet radiation (UVR)-induced suppression of cell-mediated immune function plays an important role in the development of skin cancer and induces a susceptibility to infectious disease. A similar role is suspected in humans, but we lack quantitative human data to make risk assessments of ambient solar exposure on human health. This study demonstrates that ambient levels of solar UVR, typically experienced within 1 h of exposure to noonday summer sunlight, can suppress contact hypersensitivity (CHS) responses in healthy white-skinned humans in vivo (n = 93). There was a linear relationship between increase in erythema and suppression of CHS (P < 0.001), and a moderate sunburn (two minimal erythema doses [2 MED]) was sufficient to suppress CHS in all volunteers by 93%. However, a single suberythemal exposure of either 0.25 or 0.5 MED suppressed CHS responses by 50 and 80%, respectively, in skin types I/II, whereas 1 MED only suppressed CHS by 40% in skin types III/IV. The two- to threefold greater sensitivity of skin types I/II for a given level of sunburn may play a role in their greater sensitivity to skin cancer.


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