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    Sensitivity to sunburn is associated with susceptibility to ultraviolet radiation-induced suppression of cutaneous cell-mediated immunity.

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    Authors
    Kelly, Deirdre A
    Young, Antony R
    McGregor, Jane M
    Seed, Paul T
    Potten, Christopher S
    Walker, Susan L
    Affiliation
    Department of Photobiology, St. John's Institute of Dermatology, Guy's , King's and St. Thomas' School of Medicine, King's College London, University of London, St. Thomas Hospital, London, UK.
    Issue Date
    2000-02-07
    
    Metadata
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    Abstract
    Skin cancer incidence is highest in white-skinned people. Within this group, skin types I/II (sun sensitive/tan poorly) are at greater risk than skin types III/IV (sun tolerant/tan well). Studies in mice demonstrate that ultraviolet radiation (UVR)-induced suppression of cell-mediated immune function plays an important role in the development of skin cancer and induces a susceptibility to infectious disease. A similar role is suspected in humans, but we lack quantitative human data to make risk assessments of ambient solar exposure on human health. This study demonstrates that ambient levels of solar UVR, typically experienced within 1 h of exposure to noonday summer sunlight, can suppress contact hypersensitivity (CHS) responses in healthy white-skinned humans in vivo (n = 93). There was a linear relationship between increase in erythema and suppression of CHS (P < 0.001), and a moderate sunburn (two minimal erythema doses [2 MED]) was sufficient to suppress CHS in all volunteers by 93%. However, a single suberythemal exposure of either 0.25 or 0.5 MED suppressed CHS responses by 50 and 80%, respectively, in skin types I/II, whereas 1 MED only suppressed CHS by 40% in skin types III/IV. The two- to threefold greater sensitivity of skin types I/II for a given level of sunburn may play a role in their greater sensitivity to skin cancer.
    Citation
    Sensitivity to sunburn is associated with susceptibility to ultraviolet radiation-induced suppression of cutaneous cell-mediated immunity. 2000, 191 (3):561-6 J. Exp. Med.
    Journal
    The Journal of Experimental Medicine
    URI
    http://hdl.handle.net/10541/88623
    PubMed ID
    10662801
    Type
    Article
    Language
    en
    ISSN
    0022-1007
    Collections
    All Paterson Institute for Cancer Research

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