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    Epidemiology of herpesvirus papio infection in a large captive baboon colony: similarities to Epstein-Barr virus infection in humans.

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    Authors
    Jenson, Hal B
    Ench, Yasmin
    Gao, Shou-Jiang
    Rice, Karen
    Carey, Dee
    Kennedy, Ronald C
    Arrand, John R
    Mackett, Mike
    Affiliation
    Departments of Pediatrics and Microbiology, University of Texas Health Science Center at San Antonio, 78229-3900, USA. jenson@uthscsa.edu
    Issue Date
    2000-04
    
    Metadata
    Show full item record
    Abstract
    The epidemiology of herpesvirus papio, a lymphocryptovirus similar to Epstein-Barr virus (EBV), was studied in a captive colony of >1900 baboons. Herpesvirus papio IgG antibody titers were measured by IFA. In total, 438 specimens from 296 baboons were assessed, including 116 serial specimens from 52 juveniles and 6 infants studied monthly for 1 year following birth and at age 18 months. Maternally derived antibody reached a nadir at 4 months of age. About 75% of animals at 12 months of age and >95% of animals after age 24 months demonstrated serologic evidence of herpesvirus papio infection. After age 3 years, the geometric mean titer was 1:60-75. The epidemiology of herpesvirus papio infection in baboons closely parallels that of EBV infection in humans. An animal model of lymphocryptovirus infection will facilitate investigations of human lymphocryptovirus biology.
    Citation
    Epidemiology of herpesvirus papio infection in a large captive baboon colony: similarities to Epstein-Barr virus infection in humans. 2000, 181 (4):1462-6 J. Infect. Dis.
    Journal
    The Journal of Infectious Diseases
    URI
    http://hdl.handle.net/10541/88621
    DOI
    10.1086/315385
    PubMed ID
    10762578
    Type
    Article
    Language
    en
    ISSN
    0022-1899
    ae974a485f413a2113503eed53cd6c53
    10.1086/315385
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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