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    Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones.

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    Authors
    Hargreaves, Robert H J
    Hartley, John A
    Butler, John
    Affiliation
    CRC Drug Development Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, U.K.
    Issue Date
    2000-11-01
    
    Metadata
    Show full item record
    Abstract
    Aziridinyl quinones can be activated by cellular reductases eg. DT-diaphorase and cytochrome P450 reductase to form highly reactive DNA alkylating agents. The mechanisms by which this activation and alkylation take place are many and varied. Using clinically relevant and experimental agents this review will describe many of these mechanisms. The agents discussed are Mitomycin C, EO9 and analogues, diaziridinylbenzoquinones and the pyrrolo[1, 2-alpha]benzimidazolequinones.
    Citation
    Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones. 2000, 5:E172-80 Front. Biosci.
    Journal
    Frontiers in Bioscience
    URI
    http://hdl.handle.net/10541/88618
    PubMed ID
    11056081
    Type
    Article
    Language
    en
    ISSN
    1093-4715
    Collections
    All Paterson Institute for Cancer Research

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