Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones.
Affiliation
CRC Drug Development Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, U.K.Issue Date
2000-11-01
Metadata
Show full item recordAbstract
Aziridinyl quinones can be activated by cellular reductases eg. DT-diaphorase and cytochrome P450 reductase to form highly reactive DNA alkylating agents. The mechanisms by which this activation and alkylation take place are many and varied. Using clinically relevant and experimental agents this review will describe many of these mechanisms. The agents discussed are Mitomycin C, EO9 and analogues, diaziridinylbenzoquinones and the pyrrolo[1, 2-alpha]benzimidazolequinones.Citation
Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones. 2000, 5:E172-80 Front. Biosci.Journal
Frontiers in BiosciencePubMed ID
11056081Type
ArticleLanguage
enISSN
1093-4715Collections
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