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dc.contributor.authorAttwooll, Claire L
dc.contributor.authorTariq, M
dc.contributor.authorHarris, Martin
dc.contributor.authorCoyne, J D
dc.contributor.authorTelford, Nicholas
dc.contributor.authorVarley, Jennifer
dc.date.accessioned2009-12-15T16:30:47Z
dc.date.available2009-12-15T16:30:47Z
dc.date.issued1999-12-09
dc.identifier.citationIdentification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma. 1999, 18 (52):7599-601 Oncogeneen
dc.identifier.issn0950-9232
dc.identifier.pmid10602520
dc.identifier.doi10.1038/sj.onc.1203156
dc.identifier.urihttp://hdl.handle.net/10541/88053
dc.description.abstractA proportion of extraskeletal myxoid chondrosarcomas (EMC) have been shown to have a characteristic translocation t(9;22)(q22;q12) involving the EWS gene at 22q12 and the CHN orphan nuclear receptor gene at 9q22. This translocation appears to be largely specific for EMC, but has not been detected in all such tumours. We report here a case of EMC with a t(9;17)(q22;q11.2) as the sole chromosome abnormality. We have determined that the translocation results in the fusion of the entire coding region of CHN to the N-terminal transactivation domain of RBP56/hTAFII68. This is the first report of a translocation involving RBP56/hTAFII 68, a protein with sequence homology to both EWS and TLS/FUS. The involvement of RBP56/hTAFII68 may explain some unusual features of the tumour.
dc.language.isoenen
dc.subject.meshAmino Acid Sequence
dc.subject.meshArtificial Gene Fusion
dc.subject.meshBase Sequence
dc.subject.meshChondrosarcoma
dc.subject.meshChromosomes, Human, Pair 17
dc.subject.meshChromosomes, Human, Pair 9
dc.subject.meshDNA-Binding Proteins
dc.subject.meshHumans
dc.subject.meshMolecular Sequence Data
dc.subject.meshNerve Tissue Proteins
dc.subject.meshNuclear Proteins
dc.subject.meshReceptors, Steroid
dc.subject.meshReceptors, Thyroid Hormone
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
dc.subject.meshTATA-Binding Protein Associated Factors
dc.subject.meshTranscription Factors
dc.subject.meshTranslocation, Genetic
dc.titleIdentification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, UK.en
dc.identifier.journalOncogeneen
html.description.abstractA proportion of extraskeletal myxoid chondrosarcomas (EMC) have been shown to have a characteristic translocation t(9;22)(q22;q12) involving the EWS gene at 22q12 and the CHN orphan nuclear receptor gene at 9q22. This translocation appears to be largely specific for EMC, but has not been detected in all such tumours. We report here a case of EMC with a t(9;17)(q22;q11.2) as the sole chromosome abnormality. We have determined that the translocation results in the fusion of the entire coding region of CHN to the N-terminal transactivation domain of RBP56/hTAFII68. This is the first report of a translocation involving RBP56/hTAFII 68, a protein with sequence homology to both EWS and TLS/FUS. The involvement of RBP56/hTAFII68 may explain some unusual features of the tumour.


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