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    Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma.

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    Authors
    Attwooll, Claire L
    Tariq, M
    Harris, Martin
    Coyne, J D
    Telford, Nicholas
    Varley, Jennifer
    Affiliation
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, UK.
    Issue Date
    1999-12-09
    
    Metadata
    Show full item record
    Abstract
    A proportion of extraskeletal myxoid chondrosarcomas (EMC) have been shown to have a characteristic translocation t(9;22)(q22;q12) involving the EWS gene at 22q12 and the CHN orphan nuclear receptor gene at 9q22. This translocation appears to be largely specific for EMC, but has not been detected in all such tumours. We report here a case of EMC with a t(9;17)(q22;q11.2) as the sole chromosome abnormality. We have determined that the translocation results in the fusion of the entire coding region of CHN to the N-terminal transactivation domain of RBP56/hTAFII68. This is the first report of a translocation involving RBP56/hTAFII 68, a protein with sequence homology to both EWS and TLS/FUS. The involvement of RBP56/hTAFII68 may explain some unusual features of the tumour.
    Citation
    Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma. 1999, 18 (52):7599-601 Oncogene
    Journal
    Oncogene
    URI
    http://hdl.handle.net/10541/88053
    DOI
    10.1038/sj.onc.1203156
    PubMed ID
    10602520
    Type
    Article
    Language
    en
    ISSN
    0950-9232
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.onc.1203156
    Scopus Count
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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