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    Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay.

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    Authors
    Burrill, Wayne
    Barber, James B P
    Roberts, Stephen A
    Bulman, Barbara
    Scott, David
    Affiliation
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK.
    Issue Date
    2000-12
    
    Metadata
    Show full item record
    Abstract
    Of breast cancer patients, 30% are sensitive in a lymphocyte assay of radiation-induced chromosome damage (micronucleus induction) compared with 10% of healthy controls. Twenty-two first-degree relatives of 11 sensitive patients had an average micronucleus yield significantly higher than that of 68 controls. This suggests that radiosensitivity in this assay may be an inherited characteristic associated with predisposition to breast cancer.
    Citation
    Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay. 2000, 76 (12):1617-9 Int. J. Radiat. Biol.
    Journal
    International Journal of Radiation Biology
    URI
    http://hdl.handle.net/10541/88043
    DOI
    10.1080/09553000050201109
    PubMed ID
    11133043
    Type
    Article
    Language
    en
    ISSN
    0955-3002
    ae974a485f413a2113503eed53cd6c53
    10.1080/09553000050201109
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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