Prognostic significance of c-erbB-2 protein expression in carcinoma of the cervix treated with radiotherapy.
West, Catharine M L
Gupta, Nirmal K
Wilks, Deepti P
Hendry, Jolyon H
Davidson, Susan E
Hunter, Robin D
AffiliationDepartment of Clinical Oncology, Christie Hospital (NHS) Trust, Manchester, UK.
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AbstractPURPOSE: The relationship was studied between c-erbB-2 expression and outcome in 107 carcinomas of the cervix treated with radical radiotherapy. METHODS: Formalin-fixed, paraffin-embedded sections were stained by immunohistochemistry for over-expression of the c-erbB-2 protein. A retrospective study of treatment outcome was made on patients with a median follow-up of 55 months. RESULTS: Patients with c-erbB-2-positive tumours had a significantly worse overall survival rate than those with c-crbB-2-negative tumours (P=0.019). Metastasis-free survival (i.e. recurrence outside the radiotherapy field) was also significantly worse (P < 0.001) but there were no differences in local control (i.e. recurrence within the radiotherapy field) rates (P=0.24). Bivariate log-rank analyses showed that the prognostic value of c-erbB-2 expression for metastasis-free survival was independent of disease stage, histological grade, patient age, tumour size and tumour radiosensitivity. A combination of two biological parameters yielded a high discrimination between outcome groups. Women with radiosensitive and c-erbB-2-negative tumours had a 5-year metastasis-free survival level of 70% compared to 33% for women with radioresistant, c-erbB-2-positive tumours. CONCLUSIONS: c-erbB-2 expression is an important prognostic factor for determining tumour recurrence outside the treatment field in cervix carcinomas treated with radiotherapy.
CitationPrognostic significance of c-erbB-2 protein expression in carcinoma of the cervix treated with radiotherapy. 1999, 125 (2):96-100 J. Cancer Res. Clin. Oncol.
JournalJournal of Cancer Research and Clinical Oncology
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