Positron emission tomography of murine liver metastases and the effects of treatment by combretastatin A-4.
Authors
Zhao, ShaMoore, James V
Waller, Michael L
McGown, Alan T
Hadfield, John A
Pettit, G R
Pettit, G R
Hastings, David L
Affiliation
North West Medical Physics, Christie Hospital (NHS) Trust, Manchester, UK.Issue Date
1999-03
Metadata
Show full item recordAbstract
There are major potential advantages in non-invasive measurement of preclinical tumour biology and therapeutic response in clinically relevant, internal body sites, notably the ability to follow outcome in individual animals rather than averaging results from groups. We have exploited positron emission tomography (PET) to determine the feasibility of detecting liver metastases in B6D2F1 mice using fluorine-18 fluorodeoxyglucose ([18F]FDG) both before and after treatment by the novel cytotoxic agent, combretastatin A-4. The normal distribution of [18F]FDG in the absence of disease was characterised, with the clear delineation of the brain, the heart and the urinary bladder in all studies. In untreated mice with liver metastases, a strong correlation (r2 = 0.98) was found between the quantitative estimates of [18F]FDG uptake obtained by analysis of PET images, and those obtained from ex vivo assay of liver plus metastases excised immediately after imaging. In this first series, the effective limit of resolution was in livers containing a number of small metastases (range 8-14) with a single volume equivalent of approximately 200 mm3. PET image analysis was concordant with histological measurements in showing that single intraperitoneal doses of combretastatin A-4 resulted in an average 30% volume destruction of metastatic mass by 24 h following administration.Citation
Positron emission tomography of murine liver metastases and the effects of treatment by combretastatin A-4. 1999, 26 (3):231-8 Eur J Nucl MedJournal
European Journal of Nuclear MedicineDOI
10.1007/s002590050382PubMed ID
10079313Type
ArticleLanguage
enISSN
0340-6997ae974a485f413a2113503eed53cd6c53
10.1007/s002590050382
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