Paradoxical expression of E-cadherin in prostatic bone metastases.
AffiliationDepartment of Urology, University Hospital of South Manchester, UK.
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AbstractOBJECTIVE: To determine whether the calcium-dependent cell adhesion molecule E-cadherin is expressed in metastatic deposits of prostate cancer in bone. PATIENTS AND METHODS: Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were obtained and immunohistochemically stained for E-cadherin with the monoclonal antibody HECD-1, using the streptavidin-biotin complex technique. Benign prostatic tissue was used as the control. RESULTS: Of the 10 specimens, nine showed positive expression of E-cadherin, graded as strong in four. E-cadherin expression was strongest in well-differentiated metastases and decreased with increasing tumour grade. In some specimens there were mixed patterns of expression. CONCLUSION: E-cadherin is strongly expressed in prostatic bone metastases and the degree of expression appears to reflect local tumour grade. This suggests that loss of E-cadherin expression may not be critically linked to metastatic potential.
CitationParadoxical expression of E-cadherin in prostatic bone metastases. 1999, 84 (9):1032-4 BJU Int.
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