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    Leptin binding activity changes with age: the link between leptin and puberty.

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    Authors
    Quinton, N D
    Smith, R F
    Clayton, Peter E
    Gill, M S
    Shalet, Stephen M
    Justice, S K
    Simon, S A
    Walters, S
    Postel-Vinay, M C
    Blakemore, A I
    Ross, R J
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    Affiliation
    The Division of Clinical Sciences, Sheffield University, Biomedical Research Centre, Sheffield Hallam University, United Kingdom.
    Issue Date
    1999-07
    
    Metadata
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    Abstract
    The timing of the physical transition from child to adult is determined by a biological clock that switches off the pituitary gonadal axis during infancy until puberty. Body composition (and in particular, fat mass), through leptin, are critical signals to this clock. However, no direct relationship between leptin and puberty has been demonstrated. Leptin is bound in the circulation by a high-affinity binding protein, which has been identified as a soluble leptin receptor. We found circulating levels of leptin binding activity (LBA) to be low at birth, to be high in the prepubertal years, to fall through puberty, and then to remain stable during adult life. LBA correlated with pubertal status in both boys and girls. We postulate that the fall in LBA, associated with increasing age and puberty, reflects a reduction in expression of truncated leptin receptors, and leptin is then available to the full-length receptor, which transmits the biological signal for leptin. The high levels of LBA occur during the years when the pituitary gonadal axis is quiescent. Thus, the change in LBA could explain how leptin regulates puberty.
    Citation
    Leptin binding activity changes with age: the link between leptin and puberty. 1999, 84 (7):2336-41 J. Clin. Endocrinol. Metab.
    Journal
    The Journal of Clinical Endocrinology and Metabolism
    URI
    http://hdl.handle.net/10541/88013
    DOI
    10.1210/jc.84.7.2336
    PubMed ID
    10404799
    Type
    Article
    Language
    en
    ISSN
    0021-972X
    ae974a485f413a2113503eed53cd6c53
    10.1210/jc.84.7.2336
    Scopus Count
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