AffiliationCRC Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK. firstname.lastname@example.org
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AbstractRecent studies have shown that paclitaxel (Taxol); Bristol-Myers Squibb Co., Princeton, NJ) is an active agent in the treatment of advanced non-small cell lung cancer (NSCLC). Early trials in patients with advanced NSCLC utilised a 24 h infusion schedule and reported objective tumour responses in 21 - 24% of patients. Shorter infusion schedules have equivalent efficacy, and combined results from 14 separate trials of single agent paclitaxel in advanced NSCLC show an overall tumour response rate of 26%. Alternative schedules of paclitaxel from the traditional regimen every three weeks are under active investigation, but it is premature to assess whether these will yield improved efficacy for patients with advanced NSCLC. A single multicentre randomised trial of paclitaxel versus best supportive care in advanced NSCLC showed a significant survival advantage for the chemotherapy arm. Two large randomised Phase III trials have shown that paclitaxel and cisplatin is modestly more effective than cisplatin and podophyllotoxin combinations. The addition of cisplatin or carboplatin to paclitaxel results in higher response rates than for each of the drugs as single agents, but it is unclear whether the combinations yield superior survival or quality of life compared to single agent paclitaxel, or to other paclitaxel-containing regimens.
CitationPaclitaxel: a hope for advanced non-small cell lung cancer? 1999, 8 (6):837-48 Expert Opin Investig Drugs
JournalExpert Opinion on Investigational Drugs
- Defining the role of paclitaxel in lung cancer: summary of recent studies and implications for future directions.
- Authors: Bunn PA Jr
- Issue date: 1997 Aug
- Single-agent paclitaxel in the treatment of advanced non-small cell lung cancer.
- Authors: Socinski MA
- Issue date: 1999
- High-dose therapy with carboplatin and paclitaxel in non-small cell lung cancer.
- Authors: Socinski MA, Shea TC
- Issue date: 1997 Aug
- Paclitaxel in lung cancer: 1-hour infusions given alone or in combination chemotherapy.
- Authors: Hainsworth JD, Greco FA
- Issue date: 1995 Dec
- Incorporation of paclitaxel and carboplatin in combined-modality therapy for locally advanced non-small cell lung cancer.
- Authors: Belani CP
- Issue date: 1999 Feb