• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Survivors of childhood cancer: long-term endocrine and metabolic problems dwarf the growth disturbance.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Murray, Robert D
    Brennan, Bernadette M
    Rahim, Asad
    Shalet, Stephen M
    Affiliation
    Department of Endocrinology, Christie Hospital, Manchester, UK.
    Issue Date
    1999-12
    
    Metadata
    Show full item record
    Abstract
    The long-term effects of radiotherapy and chemotherapy are becoming increasingly recognized as the cure rates of certain childhood malignancies improve. The endocrine system is particularly sensitive to cancer therapies. Long-term survivors of childhood cancer who received cranial irradiation have been shown to have lower than predicted height, an increased prevalence of obesity and reductions in strength, exercise tolerance, bone mineral density, quality of life and academic achievement. Growth hormone deficiency (GHD) is the most frequent endocrine deficiency observed following cranial irradiation. Adults with GHD resulting from primary hypothalamic-pituitary disease during childhood have been shown to exhibit a clinical picture similar to that described in long-term survivors of childhood cancer: increased fat mass and reduced lean mass, strength, exercise tolerance, bone mineral density and quality of life. This review considers the possible contribution of GHD to the adverse sequelae observed in long-term survivors of childhood malignancy and includes our preliminary experience in treating 14 adults with GHD resulting from the treatment of childhood malignancies.
    Citation
    Survivors of childhood cancer: long-term endocrine and metabolic problems dwarf the growth disturbance. 1999, 88 (433):5-12 Acta Paediatr Suppl
    Journal
    Acta Paediatrica Supplement
    URI
    http://hdl.handle.net/10541/87888
    DOI
    10.1111/j.1651-2227.1999.tb14396.x
    PubMed ID
    10626538
    Type
    Article
    Language
    en
    ISSN
    0803-5326
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1651-2227.1999.tb14396.x
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Hypothalamic-Pituitary Disorders in Childhood Cancer Survivors: Prevalence, Risk Factors and Long-Term Health Outcomes.
    • Authors: van Iersel L, Li Z, Srivastava DK, Brinkman TM, Bjornard KL, Wilson CL, Green DM, Merchant TE, Pui CH, Howell RM, Smith SA, Armstrong GT, Hudson MM, Robison LL, Ness KK, Gajjar A, Krull KR, Sklar CA, van Santen HM, Chemaitilly W
    • Issue date: 2019 Dec 1
    • Late endocrine effects of childhood cancer.
    • Authors: Rose SR, Horne VE, Howell J, Lawson SA, Rutter MM, Trotman GE, Corathers SD
    • Issue date: 2016 Jun
    • [Endocrine sequelae after treatment of pediatric cancer: From childhood to adulthood].
    • Authors: Thomas-Teinturier C, Salenave S
    • Issue date: 2015 Jul-Aug
    • Long-Term Effect of Cranial Radiotherapy on Pituitary-Hypothalamus Area in Childhood Acute Lymphoblastic Leukemia Survivors.
    • Authors: Follin C, Erfurth EM
    • Issue date: 2016 Sep
    • Late endocrine effects of cancer and cancer therapies in survivors of childhood malignancies.
    • Authors: Marques P, Van Huellen H, Fitzpatrick A, Druce M
    • Issue date: 2016 Mar
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.