Show simple item record

dc.contributor.authorSykes, Andrew J
dc.contributor.authorShanks, Jonathan H
dc.contributor.authorDavidson, Susan E
dc.date.accessioned2009-12-14T13:29:03Z
dc.date.available2009-12-14T13:29:03Z
dc.date.issued1999-02
dc.identifier.citationSmall cell carcinoma of the uterine cervix: a clinicopathological review. 1999, 14 (2):381-6 Int. J. Oncol.en
dc.identifier.issn1019-6439
dc.identifier.pmid9917517
dc.identifier.urihttp://hdl.handle.net/10541/87878
dc.description.abstractSmall cell carcinoma of the cervix is rare, with an aggressive natural history. We report on a series of 11 patients treated at the Christie Hospital, Manchester and examine their treatment and survival. Eleven patients with small cell carcinoma of the cervix were identified retrospectively from patient case notes. Treatment was individualised and included a variety of combinations of surgery radiotherapy and chemotherapy. Four patients were disease-free between 21 and 108 months (crude disease-free survival 36%). They presented with earlier disease and were older than the average for the group. They were all initially treated with radical radiotherapy. 7 patients died between 7 and 25 months. Despite combination chemotherapy, survival with advanced disease was poor. Published studies are small and fail to provide definitive answers on the best management of small cell carcinoma of the cervix. Drawing on the experience of small cell carcinoma of the lung however, combination therapy with radiotherapy, chemotherapy and possibly surgery requires careful assessment by an oncologist.
dc.language.isoenen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols
dc.subject.meshCarcinoma, Small Cell
dc.subject.meshCombined Modality Therapy
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshSurvival Analysis
dc.subject.meshUterine Cervical Neoplasms
dc.titleSmall cell carcinoma of the uterine cervix: a clinicopathological review.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.en
dc.identifier.journalInternational Journal of Oncologyen
html.description.abstractSmall cell carcinoma of the cervix is rare, with an aggressive natural history. We report on a series of 11 patients treated at the Christie Hospital, Manchester and examine their treatment and survival. Eleven patients with small cell carcinoma of the cervix were identified retrospectively from patient case notes. Treatment was individualised and included a variety of combinations of surgery radiotherapy and chemotherapy. Four patients were disease-free between 21 and 108 months (crude disease-free survival 36%). They presented with earlier disease and were older than the average for the group. They were all initially treated with radical radiotherapy. 7 patients died between 7 and 25 months. Despite combination chemotherapy, survival with advanced disease was poor. Published studies are small and fail to provide definitive answers on the best management of small cell carcinoma of the cervix. Drawing on the experience of small cell carcinoma of the lung however, combination therapy with radiotherapy, chemotherapy and possibly surgery requires careful assessment by an oncologist.


This item appears in the following Collection(s)

Show simple item record