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    Temozolomide in adult patients with advanced soft tissue sarcoma: a phase II study of the EORTC Soft Tissue and Bone Sarcoma Group.

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    Authors
    Woll, Penella J
    Judson, I
    Lee, Siow Ming
    Rodenhuis, Sjoerd
    Nielsen, O S
    Buesa, J M
    Lorigan, Paul C
    Leyvraz, Serge
    Hermans, C
    Van Glabbeke, Martine M
    Verweij, Jaap
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    Affiliation
    City Hospital, Nottingham, U.K. penella.woll@nott.ac.uk
    Issue Date
    1999-03
    
    Metadata
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    Abstract
    Temozolomide, an oral imidazotetrazine derivative, was given to 31 patients with advanced soft tissue sarcoma. The dose of 750 mg/m2 was divided over 5 consecutive days, and escalated to 1000 mg/m2 over 5 days at cycle 2 if myelosuppression no worse than common toxicity criteria grade 2 was noted in the first 28-day cycle. A total of 99 treatment cycles were given to 31 patients. The drug was well tolerated, with nausea and vomiting as the most common side-effects. Only one partial tumour response was documented, giving a response rate of 3.33%, 95% confidence interval, (CI) 0.1-17.2%. The median time to progression was 8 weeks and the median survival was 27 weeks. These results indicate that temozolomide in this schedule is not active as second-line treatment in advanced soft tissue sarcoma.
    Citation
    Temozolomide in adult patients with advanced soft tissue sarcoma: a phase II study of the EORTC Soft Tissue and Bone Sarcoma Group. 1999, 35 (3):410-2 Eur. J. Cancer
    Journal
    European Journal of Cancer
    URI
    http://hdl.handle.net/10541/87861
    DOI
    10.1016/S0959-8049(98)00403-1
    PubMed ID
    10448291
    Type
    Article
    Language
    en
    ISSN
    0959-8049
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0959-8049(98)00403-1
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