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    The diagnostic value of positron emission tomography (PET) with radiolabelled fluorodeoxyglucose (18F-FDG) in head and neck cancer.

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    Authors
    Slevin, Nicholas J
    Collins, Conor D
    Hastings, David L
    Waller, M L
    Johnson, Richard J
    Cowan, Richard A
    Birzgalis, Andrew R
    Farrington, William T
    Swindell, Ric
    Affiliation
    Department of Clinical Oncology, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    1999-06
    
    Metadata
    Show full item record
    Abstract
    Positron emission tomography (PET) scanning has recently been introduced into clinical practice but its usefulness in the management of head and neck cancer is not well defined. The aim of this prospective preliminary study was to examine the clinical value of fluorodeoxyglucose (FDG)--PET in patients with head and neck cancer treated by radiotherapy with surgery in reserve by (i) relating quantitative uptake of isotope to tumour type and histological grade and (ii) comparing the imaging findings of PET and magnetic resonance imaging (MRI) in post-radiotherapy assessment of tumour response. Twenty-one patients had pre-treatment PET and MRI scans and these were repeated four and eight months after treatment if there was no clinical relapse. Pre-treatment uptake of FDG using tumour to cerebellar ratio parameters was significantly related to the histological grade of squamous cancer (p = 0.04) but not to tumour type. Discordance of post-treatment PET/MRI findings in one case indicates a possible role for PET in the early detection of tumour recurrence. Other potential uses of PET scanning in the management of head and neck cancer are discussed.
    Citation
    The diagnostic value of positron emission tomography (PET) with radiolabelled fluorodeoxyglucose (18F-FDG) in head and neck cancer. 1999, 113 (6):548-54 J Laryngol Otol
    Journal
    The Journal of Laryngology and Otology
    URI
    http://hdl.handle.net/10541/87847
    PubMed ID
    10605586
    Type
    Article
    Language
    en
    ISSN
    0022-2151
    Collections
    All Christie Publications

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