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    Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.

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    Authors
    Ahel, Dragana
    Horejsí, Zuzana
    Wiechens, Nicola
    Polo, Sophie E
    Garcia-Wilson, Elisa
    Ahel, Ivan
    Flynn, Helen
    Skehel, Mark
    West, Stephen C
    Jackson, Stephen P
    Owen-Hughes, Tom
    Boulton, Simon J
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    Affiliation
    DNA Damage Response Laboratory, Clare Hall, London Research Institute, South Mimms EN6 3LD, UK.
    Issue Date
    2009-09-04
    
    Metadata
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    Abstract
    Posttranslational modifications play key roles in regulating chromatin plasticity. Although various chromatin-remodeling enzymes have been described that respond to specific histone modifications, little is known about the role of poly[adenosine 5'-diphosphate (ADP)-ribose] in chromatin remodeling. Here, we identify a chromatin-remodeling enzyme, ALC1 (Amplified in Liver Cancer 1, also known as CHD1L), that interacts with poly(ADP-ribose) and catalyzes PARP1-stimulated nucleosome sliding. Our results define ALC1 as a DNA damage-response protein whose role in this process is sustained by its association with known DNA repair factors and its rapid poly(ADP-ribose)-dependent recruitment to DNA damage sites. Furthermore, we show that depletion or overexpression of ALC1 results in sensitivity to DNA-damaging agents. Collectively, these results provide new insights into the mechanisms by which poly(ADP-ribose) regulates DNA repair.
    Citation
    Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. 2009, 325 (5945):1240-3 Science
    Journal
    Science
    URI
    http://hdl.handle.net/10541/87560
    DOI
    10.1126/science.1177321
    PubMed ID
    19661379
    Type
    Article
    Language
    en
    ISSN
    1095-9203
    ae974a485f413a2113503eed53cd6c53
    10.1126/science.1177321
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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