Metallothionein expression in epithelial ovarian cancer: effect of chemotherapy and prognostic significance.
AffiliationCRC Department of Drug Development, Paterson Institute for Cancer Research, Wilmslow Road, Withington, Manchester M20 4BX, United Kingdom.
MetadataShow full item record
AbstractBACKGROUND AND PURPOSE: Regimens containing platinum drugs continue to be amongst the most effective therapies for ovarian cancer. However, despite high initial response rates most patients relapse and die of their disease. Elevation of metallothionein has been implicated as a mechanism by which tumour cells become resistant to platinum anticancer drugs, although most of these studies have been carried out in vitro. This study was carried out to determine whether metallothionein expression was associated with response or survival in patients with epithelial ovarian cancer. METHODS: Metallothionein was determined by radioimmune assay using frozen ovarian tumour tissue taken either before or following cytotoxic chemotherapy. RESULTS: An increase in expression of metallothionein was seen in tumour tissue from patients who had undergone cytotoxic chemotherapy, although this did not attain significance. However, a preliminary study using biopsy material from the same patient, taken both before and after chemotherapy, showed a statistically significant increase in metallothionein. An analysis of these data showed that the level of metallothionein expression was not associated with survival or response. CONCLUSION: These data do not support the hypothesis that metallothionein expression is a determinant of response in ovarian cancer. There is some preliminary evidence from the study of paired samples which indicates that cytotoxic chemotherapy may increase metallothionein expression. An increase in metallothionein was also seen in the study using unmatched biopsies although this did not attain statistical significance, due in part to the large inter-patient variability in expression of this protein.
CitationMetallothionein expression in epithelial ovarian cancer: effect of chemotherapy and prognostic significance. 2000, 126 (12):717-21 J. Cancer Res. Clin. Oncol.
JournalJournal of Cancer Research and Clinical Oncology
- Expression of resistance gene and prognosis of chemotherapy in primary epithelial ovarian cancer.
- Authors: Yang F, Gao B, Chen W, Du E, Liang Y, Hu X, Yang X
- Issue date: 2018 Oct
- Redox protein expression predicts progression-free and overall survival in ovarian cancer patients treated with platinum-based chemotherapy.
- Authors: Woolston CM, Deen S, Al-Attar A, Shehata M, Chan SY, Martin SG
- Issue date: 2010 Nov 1
- Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients.
- Authors: Surowiak P, Materna V, Kaplenko I, Spaczyński M, Dietel M, Lage H, Zabel M
- Issue date: 2005 Sep
- Impact of adjuvant chemotherapy and surgical staging in early-stage ovarian carcinoma: European Organisation for Research and Treatment of Cancer-Adjuvant ChemoTherapy in Ovarian Neoplasm trial.
- Authors: Trimbos JB, Vergote I, Bolis G, Vermorken JB, Mangioni C, Madronal C, Franchi M, Tateo S, Zanetta G, Scarfone G, Giurgea L, Timmers P, Coens C, Pecorelli S, EORTC-ACTION collaborators. European Organisation for Research and Treatment of Cancer-Adjuvant ChemoTherapy in Ovarian Neoplasm.
- Issue date: 2003 Jan 15
- Predicting platinum resistance in primary advanced ovarian cancer patients with an in vitro resistance index.
- Authors: Hetland TE, Kærn J, Skrede M, Sandstad B, Tropé C, Davidson B, Flørenes VA
- Issue date: 2012 May