P27(KIP1) expression indicates that steroid receptor-positive cells are a non-proliferating, differentiated subpopulation of the normal human breast epithelium.
dc.contributor.author | Clarke, Robert B | |
dc.contributor.author | Howell, Anthony | |
dc.contributor.author | Potten, Christopher S | |
dc.contributor.author | Anderson, Elizabeth | |
dc.date.accessioned | 2009-11-23T12:07:05Z | |
dc.date.available | 2009-11-23T12:07:05Z | |
dc.date.issued | 2000-09 | |
dc.identifier.citation | P27(KIP1) expression indicates that steroid receptor-positive cells are a non-proliferating, differentiated subpopulation of the normal human breast epithelium. 2000, 36 Suppl 4:S28-9 Eur. J. Cancer | en |
dc.identifier.issn | 0959-8049 | |
dc.identifier.pmid | 11056305 | |
dc.identifier.doi | 10.1016/S0959-8049(00)00212-4 | |
dc.identifier.uri | http://hdl.handle.net/10541/86670 | |
dc.description.abstract | To test the hypothesis that steroid receptor-expressing cells are derived from the proliferative population, we examined expression of the p27(KIP1) inhibitor of cyclin-dependent kinase activity (a differentiation marker) while tracking the fate of proliferating cells in normal human breast tissue implanted into athymic nude mice using tritiated thymidine [3H]-dT. We identified a small number of cells that appeared to have divided just once before switching on p27(KIP1) expression. p27(KIP1)+ve cells also expressed steroid receptors, but not the Ki67 proliferation-associated antigen. These data support the hypothesis that steroid receptor-expressing cells are a differentiated population within the normal human breast epithelium. | |
dc.language.iso | en | en |
dc.subject | Tumour Suppressor Proteins | en |
dc.subject.mesh | Animals | |
dc.subject.mesh | Biological Markers | |
dc.subject.mesh | Breast | |
dc.subject.mesh | Cell Cycle Proteins | |
dc.subject.mesh | Cell Differentiation | |
dc.subject.mesh | Cyclin-Dependent Kinase Inhibitor p27 | |
dc.subject.mesh | Epithelium | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Ki-67 Antigen | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Mice, Nude | |
dc.subject.mesh | Microtubule-Associated Proteins | |
dc.subject.mesh | Tumor Suppressor Proteins | |
dc.title | P27(KIP1) expression indicates that steroid receptor-positive cells are a non-proliferating, differentiated subpopulation of the normal human breast epithelium. | en |
dc.type | Article | en |
dc.contributor.department | Clinical Research Department, Christie Hospital, M20 4BX, Manchester, UK. | en |
dc.identifier.journal | European Journal of Cancer | en |
html.description.abstract | To test the hypothesis that steroid receptor-expressing cells are derived from the proliferative population, we examined expression of the p27(KIP1) inhibitor of cyclin-dependent kinase activity (a differentiation marker) while tracking the fate of proliferating cells in normal human breast tissue implanted into athymic nude mice using tritiated thymidine [3H]-dT. We identified a small number of cells that appeared to have divided just once before switching on p27(KIP1) expression. p27(KIP1)+ve cells also expressed steroid receptors, but not the Ki67 proliferation-associated antigen. These data support the hypothesis that steroid receptor-expressing cells are a differentiated population within the normal human breast epithelium. |