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dc.contributor.authorClarke, Robert Ben
dc.contributor.authorHowell, Anthonyen
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorAnderson, Elizabethen
dc.date.accessioned2009-11-23T12:07:05Z
dc.date.available2009-11-23T12:07:05Z
dc.date.issued2000-09
dc.identifier.citationP27(KIP1) expression indicates that steroid receptor-positive cells are a non-proliferating, differentiated subpopulation of the normal human breast epithelium. 2000, 36 Suppl 4:S28-9 Eur. J. Canceren
dc.identifier.issn0959-8049
dc.identifier.pmid11056305
dc.identifier.doi10.1016/S0959-8049(00)00212-4
dc.identifier.urihttp://hdl.handle.net/10541/86670
dc.description.abstractTo test the hypothesis that steroid receptor-expressing cells are derived from the proliferative population, we examined expression of the p27(KIP1) inhibitor of cyclin-dependent kinase activity (a differentiation marker) while tracking the fate of proliferating cells in normal human breast tissue implanted into athymic nude mice using tritiated thymidine [3H]-dT. We identified a small number of cells that appeared to have divided just once before switching on p27(KIP1) expression. p27(KIP1)+ve cells also expressed steroid receptors, but not the Ki67 proliferation-associated antigen. These data support the hypothesis that steroid receptor-expressing cells are a differentiated population within the normal human breast epithelium.
dc.language.isoenen
dc.subjectTumour Suppressor Proteinsen
dc.subject.meshAnimals
dc.subject.meshBiological Markers
dc.subject.meshBreast
dc.subject.meshCell Cycle Proteins
dc.subject.meshCell Differentiation
dc.subject.meshCyclin-Dependent Kinase Inhibitor p27
dc.subject.meshEpithelium
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshKi-67 Antigen
dc.subject.meshMice
dc.subject.meshMice, Nude
dc.subject.meshMicrotubule-Associated Proteins
dc.subject.meshTumor Suppressor Proteins
dc.titleP27(KIP1) expression indicates that steroid receptor-positive cells are a non-proliferating, differentiated subpopulation of the normal human breast epithelium.en
dc.typeArticleen
dc.contributor.departmentClinical Research Department, Christie Hospital, M20 4BX, Manchester, UK.en
dc.identifier.journalEuropean Journal of Canceren
html.description.abstractTo test the hypothesis that steroid receptor-expressing cells are derived from the proliferative population, we examined expression of the p27(KIP1) inhibitor of cyclin-dependent kinase activity (a differentiation marker) while tracking the fate of proliferating cells in normal human breast tissue implanted into athymic nude mice using tritiated thymidine [3H]-dT. We identified a small number of cells that appeared to have divided just once before switching on p27(KIP1) expression. p27(KIP1)+ve cells also expressed steroid receptors, but not the Ki67 proliferation-associated antigen. These data support the hypothesis that steroid receptor-expressing cells are a differentiated population within the normal human breast epithelium.


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