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    p53 and related proteins in epithelial ovarian cancer.

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    Authors
    Sengupta, P S
    McGown, Alan T
    Bajaj, V
    Blackhall, Fiona H
    Swindell, Ric
    Bromley, Michael
    Shanks, Jonathan H
    Ward, Timothy H
    Buckley, C H
    Reynolds, K
    Slade, Richard J
    Jayson, Gordon C
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    Affiliation
    Cancer Research Campaign Department of Medical Oncology, Christie Hospital National Health Trust, Withington, Manchester, UK.
    Issue Date
    2000-12
    
    Metadata
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    Abstract
    We conducted a retrospective immunohistochemical evaluation of the prognostic significance of the expression of p53 and the related proteins Bax, Bcl-2, growth arrest and DNA damage (Gadd45), murine double minute 2 (Mdm2) and p21(WAF1/CIP1) in chemonaive tumours taken from 66 patients with ovarian cancer. Ki-67 expression (a marker of cell proliferation) was also evaluated immunohistochemically, while apoptosis within malignant cells was determined with the terminal deoxynucleotidyltransferase-mediated dUTP nick-end labelling (TUNEL) assay. The expression of each of the following proteins was significantly associated in the tumours (P < 0.05 unless otherwise stated): Bax with Bcl-2 (P < 0.01); Bax with Mdm2; p21(WAF1/CIP1) with Gadd45 (P < 0.01); p21(WAF1/CIP1) with p53; p53 with Mdm2. Univariate analysis showed that expression of p53, Bax, bulk residual disease and International Federation of Gynecology and Obstetricians (FIGO) stage were all strongly correlated with response to chemotherapy (P < 0.01). Similarly, the FIGO stage and Ki-67 expression (P < 0.01), as well as pathological subtype and bulk residual disease (P < 0.05), were prognostic factors for disease progression. The FIGO stage and Ki-67 expression were significant prognostic factors for overall survival (P < 0.01), with Gadd45 expression and pathological subtype also significant (P < 0.05) in a univariate analysis. Multivariate analysis for response to chemotherapy showed that expression of p53, Bax and FIGO stage were all independent prognostic factors (P < 0.01). The FIGO stage was the most important independent prognostic factor for progression and survival on multivariate analysis (P < 0.01). However, Ki-67 expression was also an independent prognostic factor for disease progression (P < 0.05) and approached significance for survival (P = 0.055). Taken together, these data suggest that determination of Ki-67 expression could supplement established prognostic factors.
    Citation
    p53 and related proteins in epithelial ovarian cancer. 2000, 36 (18):2317-28 Eur. J. Cancer
    Journal
    European Journal of Cancer
    URI
    http://hdl.handle.net/10541/86661
    DOI
    10.1016/S0959-8049(00)00301-4
    PubMed ID
    11094305
    Type
    Article
    Language
    en
    ISSN
    0959-8049
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0959-8049(00)00301-4
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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